Sacubitril/valsartan in patients with mildly reduced or preserved ejection fraction and worsening heart failure: A review

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Abstract

Heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction are associated with significant morbidity and mortality, as well as growing economic burden. This review describes recent studies on the use of sacubitril/valsartan in heart failure patients with mildly reduced or preserved ejection fraction.

About the authors

Igor V. Zhirov

Chazov National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: izhirov@mail.ru
ORCID iD: 0000-0002-4066-2661

Medicorum Scientiarum Doctor, Investigator Princeps Department of Morborum Myocardialium et Cordis Defectus, Professor Department of Cardiologiae

Russian Federation, Moscow; Moscow

Natalia V. Safronova

Chazov National Medical Research Center of Cardiology

Email: izhirov@mail.ru
ORCID iD: 0000-0001-6624-3804

Candidatus Scientiarum Medical, Junior Investigator, Department of Myocardial Morborum et Cordis Defectus

Russian Federation, Moscow

Sergey N. Tereshchenko

Chazov National Medical Research Center of Cardiology

Email: izhirov@mail.ru
ORCID iD: 0000-0001-9234-6129

Doctor of Medical Sciences, Professor, Head of Department myocardial diseases and heart failure

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. ECG of patient K., 72 years old. Sinus rhythm, heart rate 65 bpm, left axis deviation, the voltage criteria for left ventricular hypertrophy, and strain pattern (downsloping ST depression and negative T wave at I, II, AVL, and precordial leads).

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3. Fig. 2. Patient K., 72 years old. Apical two-chamber position, left atrial volume measurement.

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