Email this article Analysis of fatal outcomes of meningococcal infection in adults
- Authors: Zhdanov K.V.1, Kovalenko A.N.1, Chirsky V.S.1, Gusev D.A.2, Nalivkina N.A.1, Zinserling V.A.2, Grigoriev S.G.1, Khairutdinova R.A.1, Isakov A.N.2, Sharabkhanov V.V.1
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Affiliations:
- Kirov Military Medical Academy
- Botkin Clinical Infectious Diseases Hospital
- Issue: Vol 94, No 11 (2022)
- Pages: 1252-1256
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/232336
- DOI: https://doi.org/10.26442/00403660.2022.11.201931
- ID: 232336
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Abstract
Clinical characteristics and pathomorphological manifestations in 69 patients aged 18 to 86 years with a fatal outcome of the disease were examined in order to analyze the causes of severe course and high mortality of generalized forms meningococcal infection. It was found that the main clinical form was meningococcemia (90%), in the majority in combination with meningitis (52%). The fulminant course in 77% of patients with meningococcal sepsis manifested itself as a sudden onset, rapid development of typical symptoms. Hemorrhagic exanthema was detected on the first day of meningococcemia. The leading complications and critical conditions were infectious-toxic shock, disseminated intravascular coagulation and acute adrenal insufficiency (Waterhouse–Friederiksen syndrome). The severe course of meningitis (in 10%) led to the development of cerebral coma, the morphological substrate of which was edema – swelling of the brain.
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##article.viewOnOriginalSite##About the authors
Konstantin V. Zhdanov
Kirov Military Medical Academy
Email: 9268754@mail.ru
ORCID iD: 0000-0002-3679-1874
чл.-кор. РАН, д-р мед. наук, проф., гл. инфекционист МО РФ – начальник каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний)
Russian Federation, Saint PetersburgAleksandr N. Kovalenko
Kirov Military Medical Academy
Author for correspondence.
Email: 9268754@mail.ru
ORCID iD: 0000-0002-2976-8051
д-р мед. наук, доц. каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний)
Russian Federation, Saint PetersburgVadim S. Chirsky
Kirov Military Medical Academy
Email: 9268754@mail.ru
ORCID iD: 0000-0003-3215-3901
д-р мед. наук, проф., зав. каф. патологической анатомии
Russian Federation, Saint PetersburgDenis A. Gusev
Botkin Clinical Infectious Diseases Hospital
Email: 9268754@mail.ru
ORCID iD: 0000-0001-9202-3231
д-р мед. наук, проф., глав. врач
Russian Federation, Saint PetersburgNatalia A. Nalivkina
Kirov Military Medical Academy
Email: 9268754@mail.ru
ORCID iD: 0000-0001-9592-6858
преподаватель каф. патологической анатомии
Russian Federation, Saint PetersburgVsevolod A. Zinserling
Botkin Clinical Infectious Diseases Hospital
Email: 9268754@mail.ru
ORCID iD: 0000-0001-7361-1927
врач-патологоанатом
Russian Federation, Saint PetersburgStepan G. Grigoriev
Kirov Military Medical Academy
Email: 9268754@mail.ru
ORCID iD: 0000-0003-1095-1216
д-р мед. наук, проф., ст. науч. сотр. НИО (Всеармейский медицинский регистр МО РФ) НИЦ
Russian Federation, Saint PetersburgRegina A. Khairutdinova
Kirov Military Medical Academy
Email: 9268754@mail.ru
ORCID iD: 0000-0002-3762-332X
анестезиолог-реаниматолог отд-ния реанимации и интенсивной терапии клиники нервных болезней
Russian Federation, Saint PetersburgArtem N. Isakov
Botkin Clinical Infectious Diseases Hospital
Email: 9268754@mail.ru
ORCID iD: 0000-0001-7294-8560
врач-патологоанатом
Russian Federation, Saint PetersburgValerian V. Sharabkhanov
Kirov Military Medical Academy
Email: 9268754@mail.ru
ORCID iD: 0000-0002-0526-6006
адъюнкт каф. инфекционных болезней
Russian Federation, Saint PetersburgReferences
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