Email this article Adherence to treatment of hematological malignancies patients with anxiety and depression
- Authors: Vybornykh D.E.1, Moiseeva T.N.1, Gemdzhian E.G.1, Gaponova T.V.1, Esina L.V.1,2, Kolgaeva E.I.1, Novikova D.V.1
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Affiliations:
- National Medical Research Center for Hematology
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 95, No 7 (2023)
- Pages: 554-559
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/148296
- DOI: https://doi.org/10.26442/00403660.2023.07.202291
- ID: 148296
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Abstract
Aim. To establish the features of the influence of anxiety and depressive disorders on treatment adherence, as well as to clarify the factors associated with it in hematologic malignancies patients.
Materials and methods. The study included 117 patients: 51 men and 66 women, aged 19 to 67 years, with Hodgkin's lymphoma – 88, acute lymphoblastic leukemia – 16 and aplastic anemia – 13 patients. Patients were examined by psychiatrist using the Brief Psychiatric Rating Scale, as well as some psychometric methods.
Results. Anxiety-depressive spectrum disorders were detected in 36 (40.9%) patients with Hodgkin's lymphoma and 8 (50%) with acute lymphoblastic leukemia, in the aplastic anemia group there were three (23.1%) of such patients. It was found that the average adherence to treatment was in 2/3 of patients, low and high – in the remaining 1/3 of patients. With medium and low adherence to treatment, the risk of adverse events increases by an average of 1.7 times. The adherence to treatment it is significantly higher in patients older than 45 years. Signs of depression that negatively correlated with adherence to treatment were pessimism and disruption of social ties. Adherence to treatment significantly positively correlates with the following types of attitudes towards the disease: anosognosic, hypochondriac and egocentric, and significantly negatively correlates with the following types of attitudes towards the disease: anxious, melancholic and dysphoric.
Conclusion. Anxiety/depressive disorders contribute to reduced adherence of hematologic malignancies patients to treatment. Their correction and increased adherence should be carried out jointly by hematologists and mental health professionals.
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##article.viewOnOriginalSite##About the authors
Dmitry E. Vybornykh
National Medical Research Center for Hematology
Author for correspondence.
Email: dvyb@yandex.ru
ORCID iD: 0000-0001-7506-4947
д-р мед. наук, зав. лаб. по изучению психических и неврологических расстройств при заболеваниях системы крови
Russian Federation, MoscowTatiana N. Moiseeva
National Medical Research Center for Hematology
Email: dvyb@yandex.ru
ORCID iD: 0000-0001-9591-8508
канд. мед. наук, зав. консультативным гематологическим отд-нием с дневным стационаром по проведению интенсивной высокодозной химиотерапии
Russian Federation, MoscowEduard G. Gemdzhian
National Medical Research Center for Hematology
Email: dvyb@yandex.ru
ORCID iD: 0000-0002-8357-977X
биостатистик лаб. по изучению психических и неврологических расстройств при заболеваниях системы крови
Russian Federation, MoscowTatiana V. Gaponova
National Medical Research Center for Hematology
Email: dvyb@yandex.ru
ORCID iD: 0000-0002-9684-5045
канд. мед. наук, первый зам. ген. дир.
Russian Federation, MoscowLiubov V. Esina
National Medical Research Center for Hematology; Sechenov First Moscow State Medical University (Sechenov University)
Email: dvyb@yandex.ru
ORCID iD: 0000-0001-7253-5694
мед. психолог лаб. по изучению психических и неврологических расстройств при заболеваниях системы крови, ассистент каф. педагогики и медицинской психологии
Russian Federation, Moscow; MoscowElmira I. Kolgaeva
National Medical Research Center for Hematology
Email: dvyb@yandex.ru
ORCID iD: 0000-0002-1491-620X
врач-гематолог отд-ния химиотерапии гемобластозов и трансплантации костного мозга и гемопоэтических стволовых клеток
Russian Federation, MoscowDaria V. Novikova
National Medical Research Center for Hematology
Email: dvyb@yandex.ru
ORCID iD: 0000-0002-2080-4327
врач-гематолог консультативного гематологического отд-ния с дневным стационаром по проведению интенсивной высокодозной химиотерапии
Russian Federation, MoscowReferences
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