Anemia and quality of life of chronic kidney disease patients on renal replacement therapy by programmed hemodialysis

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Abstract

Aim. To study relationship between anemia and health-related quality of life (HRQOL) of chronic kidney disease stage 5 patients (CKD) undergoing renal replacement therapy by programmed hemodialysis.

Materials and Methods. The study was conducted on the basis of dialysis centers/departments in Moscow. The Russian-language version of the KDQOL-SFTM questionnaire, validated in Russia, was used to assess the HRQOL of patients on hemodialysis. A total of 723 patients were interviewed. Hemoglobin (Hb) levels were assessed in 442 patients based on outpatient records. To identify the relationship between Hb level and HRQOL scales, a correlation analysis was performed, as well as a HRQOL analysis in the three groups differing in hemoglobin levels (<100; 100-120 and >120 g/l). Statistical data processing was carried by SPSS.22 and using parametric and nonparametric statistical methods.

Results. Correlation relationship was revealed between Hb and HRQOL of patients on hemodialysis on the scales "symptoms/problems", "pain", "vital activity, energy" and "total physical component of health". According to the scales "symptoms/problems" and "vital activity, energy", higher rates were noted among patients with Hb higher than the target level, which confirms the recommendations concerning the possibility of achieving higher Hb among individual patients who have not serious concomitant diseases and cardiovascular complications in order to improve their quality of life.

Conclusion. HRQOL assessment is important tool for planning and evaluating the effectiveness of anemia drug therapy among patients with CKD on hemodialysis.

About the authors

Oleg N. Kotenko

Moscow City Clinical Hospital № 52

Email: labolyan@mail.ru
ORCID iD: 0000-0001-8264-7374

канд. мед. наук, рук. Московского городского научно-практического центра нефрологии и патологии трансплантированной почки, гл. внештат. специалист-нефролог

Russian Federation, Moscow

Liubov V. Abolyan

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: labolyan@mail.ru
ORCID iD: 0000-0002-7644-8771

д-р мед. наук, проф. каф. общественного здоровья и здравоохранения им. Н.А. Семашко

Russian Federation, Moscow

Vladislav Iu. Kuteinikov

Sechenov First Moscow State Medical University (Sechenov University)

Email: labolyan@mail.ru
ORCID iD: 0000-0002-6299-4261

аспирант каф. общественного здоровья и здравоохранения им. Н.А. Семашко

Russian Federation, Moscow

Vladimir E. Vinogradov

Moscow City Clinical Hospital № 52; Research Institute for Healthcare Organization and Medical Management

Email: labolyan@mail.ru
ORCID iD: 0000-0002-2499-4770

зав. консультативно-диагностическим нефрологическим отд-нием, специалист организационно-методического отд. по нефрологии

Russian Federation, Moscow; Moscow

Victor V. Fomin

Sechenov First Moscow State Medical University (Sechenov University)

Email: labolyan@mail.ru
ORCID iD: 0000-0002-2682-4417

чл.-кор. РАН, д-р мед. наук, проф., проректор по клинической работе и дополнительному профессиональному образованию, зав. каф. факультетской терапии №1 Института клинической медицины им. Н.В. Склифосовского, гл. внештат. специалист общей врачебной практики

Russian Federation, Moscow

References

  1. Hazin MAA. Anemia in chronic kidney disease. Rev Assoc Med Bras. 2020;66(Suppl. 1):s55-8. doi: 10.1590/1806-9282.66.S1.55
  2. Stauffer ME, Fan T. Prevalence of anemia in chronic kidney disease in the United States. PLoS One. 2014;9(1):e84943. doi: 10.1371/journal.pone.0084943
  3. Sofue T, Nakagawa N, Kanda E, et al. Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, crosssectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB). PLoS One. 2020;15(7):e0236132. doi: 10.1371/journal.pone.0236132
  4. Li Y, Shi H, Wang WM, et al. Prevalence, awareness, and treatment of anemia in Chinese patients with nondialysis chronic kidney disease: first multicenter, cross-sectional study. Medicine (Baltimore). 2016;95(24):e3872. doi: 10.1097/MD.0000000000003872
  5. Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group. KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Kidney Inter Suppl. 2012;2(4):279-335
  6. van Haalen H, Jackson J, Spinowitz B, et al. Impact of chronic kidney disease and anemia on health-related quality of life and work productivity: analysis of multinational real-world data. BMC Nephrol. 2020;21(1):88. doi: 10.1186/s12882-020-01746-4
  7. Смирнов А.В., Ватазин А.В., Добронравов В.А., и др. Клинические рекомендации. Хроническая болезнь почек (ХБП). Нефрология. 2021;25(5):10-84 [Smirnov AV, Vatazin AV, Dobronravov VA, et al. Clinical recommendations. Chronic kidney disease (CKD). Nephrology (Saint-Petersburg). 2021;25(5):10-84 (in Russian)]. doi: 10.36485/1561-6274-2021-25-5-10-84
  8. Mathias SD, Blum SI, Sikirica V, et al. Symptoms and impacts in anemia of chronic kidney disease. Patient Rep Outcomes. 2020;4(1):64. doi: 10.1186/s41687-020-00215-8
  9. Guedes M, Guetter CR, Erbano LHO, et al. Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis. BMC Nephrol. 2020;21(1):259. doi: 10.1186/s12882-020-01912-8
  10. Милованов Ю.С., Добросмыслов И.А., Милованова С.Ю., и др. Качество жизни больных хронической болезнью почек на заместительной почечной терапии. Терапевтический архив. 2018;90(6):89-91 [Milovanov YuS, Dobrosmyslov IA, Milovanova SYu, et al. Quality of life of chronic kidney disease patients on renal replacement therapy. Terapevticheskii Arkhiv. (Ter. Arkh.). 2018;90(6):89-91 (in Russian)]. doi: 10.26442/terarkh201890689-91
  11. Воробьев П.А., Безмельницына Л.Ю. Исследование эпидемиологии и качества жизни больных с анемией при хронической почечной недостаточности, находящихся на программном гемодиализе. Часть 2. Качество жизни и затраты на применение препаратов эритропоэтина. Клиническая нефрология. 2011;2:45-8 [Vorobyev PA, Bezmeljnicyna LYu. Research of epidemiology and quality of life of patients with anaemia in chronic renal insufficiency, who are on program hemodialysis. Part 2. Quality of life and costs of erythropoietin. Klinicheskaya nefrologiya. 2011;2:45-8 (in Russian)].
  12. Дору-Товт В.П. Влияние анемии на показатели качества жизни у больных на программном гемодиализе. СПб., 2011 [Doru-Tovt VP. Vliianie anemii na pokazateli kachestva zhizni u bol'nykh na programmnom gemodialize. Saint Petersburg, 2011 (in Russian)].
  13. Васильева И.А., Смирнов А.В. Оценка качества жизни больных на гемодиализе при помощи опросника KDQOL-SFTM. Нефрология. 2017;21(4):55-60 [Vasilieva IA, Smirnov AV. Evaluation of quality of life in hemodialisys patient using the KDQOL-SFTM questionnaire. Nefrologiya. 2017;21(4):55-60 (in Russian)]. doi: 10.24884/1561-6274-2017-21-4-55-60
  14. Shiferaw WS, Akalu TY, Aynalem YA, Ethiop J. Risk Factors for Anemia in Patients with Chronic Renal Failure: A Systematic Review and Meta-Analysis. Health Sci. 2020;30(5):829-42. doi: 10.4314/ejhs.v30i5.23
  15. Крылова М.И., Ермоленко В.М., Шутов Е.В. Качество жизни у больных с терминальной уремией на лечении гемодиализом и перитонеальным диализом. Нефрология и диализ. 2010;12(3):192-6 [Krylova MI, Ermolenko VM, Shutov EV. Quality of life in patients with terminal uremia in the treatment of hemodialysis and peritoneal dialysis. Nefrologiya i dializ. 2010;12(3):192-6 (in Russian)].
  16. Иевлев Е.Н., Казакова И.А. Оценка качества жизни больных на гемодиализе при помощи опросника KDQOL-SFTM. Нефрология. 2017;21(4):55-60 [Ievlev EN, Kazakova IA. Evaluation of quality of life in hemodialysis patients using the KDQOL-SFTM Questionnaire. Nephrology (Saint-Petersburg). 2017;21(4):55-60 (in Russian)]. doi: 10.24884/1561-6274-2017-21-4-55-60
  17. Новик А.А., Ионова Т.И. Руководство по исследованию качества жизни в медицине. 4-е изд., перераб. и доп. Под. ред. Ю.Л. Шевченко. М.: Издательство Национального медико-хирургического центра им. Н.И. Пирогова, 2021 [Novik AA, Ionova TI. Rukovodstvo po issledovaniiu kachestva zhizni v meditsine. (4-e izd., pererab. i dop.). Pod red. YuL Shevchenko. Moscow: Izdatel'stvo Natsional'nogo mediko-khirurgicheskogo tsentra im. NI Pirogova, 2021 (in Russian)].
  18. Амирджанова В.Н., Горячев Д.В., Коршунов Н.И., и др. Популяционные показатели качества жизни по опроснику SF-36 (результаты многоцентрового исследования качества жизни «Мираж»). Научно- практическая ревматология. 2008;46(1):36-48 [Amirdjanova VN, Goryachev DV, Korshunov NI, et al. SF-36 questionnaire population quality of life indices Objective. Rheumatology Science and Practice. 2008;46(1):36-48 (in Russian). doi: 10.14412/1995-4484-2008-852
  19. Finkelstein FO, Finkelstein SH. The Impact of Anemia Treatment on Health-Related Quality of Life in Patients With Chronic Kidney Disease in the Contemporary Era. Adv Chronic Kidney Dis. 2019;26(4):250-2. doi: 10.1053/j.ackd.2019.04.003
  20. Spinowitz B, Pecoits-Filho R, Winkelmayer WC, et al. Economic and quality of life burden of anemia on patients with CKD on dialysis: a systematic review. J Med Econ. 2019;22(6):593-604. doi: 10.1080/13696998.2019.1588738
  21. Locatelli F, Bárány P, Covic A, et al. ERAEDTA ERBP Advisory Board. Kidney Disease: Improving Global Outcomes guidelines on anemia management in chronic kidney disease: a European Renal Best Practice position statement. Nephrol Dial Transplant. 2013;28(6):1346-59. doi: 10.1093/ndt/gft033
  22. Михайлова Н.А. Возможности оптимизации ЭПО-терапии у пациентов с ренальной анемией. Эффективная фармакотерапия. 2021;17(3):24-32 [Mikhaylova, NA. Possibilities of EPO-Therapy Optimizing in Patients with Renal Anemia. Effektivnaya farmakoterapiya. 2021;17(3):24-32 (in Russian)]. doi: 10.33978/2307-3586-2021-17-3-24-32

Supplementary files

Supplementary Files
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2. Fig. 1. Significant differences of the quality of life scales in three groups of patients with stage 5 CKD on hemodialysis.

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