Principles of treatment of different forms of alcoholic liver disease: A review

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Abstract

The review considers the principles of treatment of various forms of alcoholic liver disease from the point of view of the evidence base and clinical recommendations. The main therapy for severe alcoholic hepatitis is systemic glucocorticosteroids, their effect on survival is increased by the addition of antioxidants (N-acetylcysteine, ademethionine). The effect of ademetionine on the life expectancy of patients with alcoholic cirrhosis of Child–Pugh class A and B has been proven. The treatment of patients with mild forms of alcoholic liver disease is not well developed, and the evidence base for most of the drugs used is modest.

About the authors

Karina L. Raikhelson

Saint Petersburg State University

Email: kraikhelson@mail.ru
ORCID iD: 0000-0002-8821-6142

д-р мед. наук, проф. Научно-клинического и образовательного центра гастроэнтерологии и гепатологии

Russian Federation, Saint Petersburg

Elina A. Kondrashina

Saint Petersburg State University

Email: elalkon@rambler.ru
ORCID iD: 0000-0002-0142-0264

канд. мед. наук, доц. Научно-клинического и образовательного центра гастроэнтерологии и гепатологии

Russian Federation, Saint Petersburg

Ekaterina V. Pazenko

Saint Petersburg State University

Author for correspondence.
Email: kaboi@rambler.ru
ORCID iD: 0000-0002-7590-8932

мл. науч. сотр. Научно-клинического и образовательного центра гастроэнтерологии и гепатологии

Russian Federation, Saint Petersburg

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2. Fig. 1. Decision tree for patients with acute alcoholic hepatitis.

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Copyright (c) 2023 Raikhelson K.L., Kondrashina E.A., Pazenko E.V.

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