Lupus nephritis in the XXI century
- Authors: Bobkova I.N.1, Moiseev S.V.1, Lysenko L.V.1, Kamyshova E.S.1
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Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 94, No 6 (2022)
- Pages: 713-717
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/109606
- DOI: https://doi.org/10.26442/00403660.2022.06.201559
- ID: 109606
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Abstract
Lupus nephritis (LN) is the most common organ lesion in systemic lupus erythematosus (SLE), developing in 40–50% of patients. Due to immunosuppressive therapy, the survival of patients with SLE has increased significantly over the past 50 years, and the proportion of severe kidney damage in the death structure has decreased. However, LN relapses and complications of immunosuppression, accelerated atherogenesis, concomitant diseases lead to the accumulation of organ damage and an increased risk of death. The article consideres the place of kidney damage in the SLE, the risk factors for LN development, the main renal histopathological changes, it identifies a number of issues that need to be addressed to optimize treatment and improve LN long-term outcomes, including, the revision of pathogenetic therapy regimens with restriction of glucocorticosteroids and prescribing drugs with steroid-sparing activity, the integration of new drugs for LN treatment, wider use of modern nephroprotection capabilities.
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##article.viewOnOriginalSite##About the authors
Irina N. Bobkova
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: irbo.mma@mail.ru
ORCID iD: 0000-0002-8007-5680
д-р мед. наук, проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowSergey V. Moiseev
Sechenov First Moscow State Medical University (Sechenov University)
Email: irbo.mma@mail.ru
ORCID iD: 0000-0002-7232-4640
акад. РАН, д-р мед. наук, проф., проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, дир. Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3
Russian Federation, MoscowLidia V. Lysenko
Sechenov First Moscow State Medical University (Sechenov University)
Email: irbo.mma@mail.ru
ORCID iD: 0000-0002-1166-7308
д-р мед. наук, проф., зав. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowElena S. Kamyshova
Sechenov First Moscow State Medical University (Sechenov University)
Email: irbo.mma@mail.ru
ORCID iD: 0000-0002-1823-0125
канд. мед. наук, доц. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowReferences
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