Email this article Achievement of clinical-laboratory and ASAS-partial remission in patients with early axial spondyloarthritis according to the ESAC cohort at the 3rd year of follow-up
- Authors: Timokhina D.G.1, Dubinina T.V.1, Demina A.B.1, Krichevskaya O.A.1, Erdes S.F.1
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Affiliations:
- Nasonova Research Institute of Rheumatology
- Issue: Vol 94, No 5 (2022)
- Pages: 642-646
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/108781
- DOI: https://doi.org/10.26442/00403660.2022.05.201496
- ID: 108781
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Abstract
Background. According to the «treat-to-target strategy» for spondyloarthritis (SpA), the main goal is to achieve clinical remission or inactive disease. In 2001, the Assessment of Spondyloarhtritis International Society (ASAS) formulated the ASAS criteria for partial remission, and the Russian expert group for the study of SpA identified clinical-laboratory remission (no clinical manifestations of the disease that persists for 6 months in the presence of normal values of C-reactive protein and erythrocyte sedimentation rate), magnetic resonance imaging (MRI) remission and complete remission (a combination of clinical-laboratory and MRI remission).
Aim. To determine the frequency of achieving clinical-laboratory and ASAS partial remission in patients with early axial SpA (axSpA) at the 3rd year of follow-up.
Materials and methods. The study included patients from the ESAC cohort (Early SpondyloArthritis Cohort), formed at the Nasonova Research Institute of Rheumatology (Moscow). Currently, the cohort includes 175 patients with axSpA. The analysis included 66 patients followed for at least 3 years, of which 37 (56%) were men and 29 (44%) were women. The average age of the patients was 31.5 (±5.7) years, the average duration of the disease was 22.1 (±17.0) months, 63 (95.4%) patients had HLA-B27 antigen.
Results. Clinical-laboratory remission was achieved by 21 (31.8%) patients with early axSpA at the 3rd year of follow-up, ASAS partial remission – by 29 (44.0%) patients.
Conclusion. In the 3rd year of follow-up of patients with early axSpA, 32% of patients achieved clinical-laboratory remission, and 44% of patients achieved ASAS partial remission. More than 40% of patients with early axial spondyloarthritis achieve remission while taking non-steroidal anti-inflammatory drugs.
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##article.viewOnOriginalSite##About the authors
Daria G. Timokhina
Nasonova Research Institute of Rheumatology
Author for correspondence.
Email: rumiantceva01@gmail.com
ORCID iD: 0000-0002-1684-1213
канд. мед. наук, мл. науч. сотр. лаб. аксиального спондилоартрита
Russian Federation, MoscowTatyana V. Dubinina
Nasonova Research Institute of Rheumatology
Email: rumiantceva01@gmail.com
ORCID iD: 0000-0002-1771-6246
канд. мед. наук, зав. лаб. аксиального спондилоартрита
Russian Federation, MoscowAnastasia B. Demina
Nasonova Research Institute of Rheumatology
Email: rumiantceva01@gmail.com
ORCID iD: 0000-0002-3106-3296
канд. мед. наук, науч. сотр. лаб. аксиального спондилоартрита
Russian Federation, MoscowOlga A. Krichevskaya
Nasonova Research Institute of Rheumatology
Email: rumiantceva01@gmail.com
ORCID iD: 0000-0002-1109-9865
канд. мед. наук, науч. сотр. лаб. аксиального спондилоартрита
Russian Federation, MoscowShandor F. Erdes
Nasonova Research Institute of Rheumatology
Email: rumiantceva01@gmail.com
ORCID iD: 0000-0003-3195-5187
д-р мед. наук, проф., вед. науч. сотр. лаб. аксиального спондилоартрита
Russian Federation, MoscowReferences
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