The burden of progression of psoriatic arthritis. All-Russian register data
- Authors: Korsakova Y.L.1, Loginova E.Y.1, Korotaeva T.V.1, Gubar E.E.1, Glukhova S.I.1, Vasilenko E.A.2, Nasonov E.L.1,3
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Affiliations:
- Nasonova Research Institute of Rheumatology
- Mechnikov North-Western State Medical University
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 94, No 5 (2022)
- Pages: 622-627
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/108778
- DOI: https://doi.org/10.26442/00403660.2022.05.201506
- ID: 108778
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Abstract
Background. Psoriatic arthritis (PsA) is a complex immune-mediated disease in which a third of patients with psoriasis (PsO) have a inflammatory lesion of both the musculoskeletal system (peripheral joints and axial structures) and extra-articular manifestations (dactylitis, enthesitis, nail PsO, uveitis and inflammatory bowel disease).
Aim. To assess the burden of PsA progression in real practice according to the Russian register of PsA patients.
Materials and methods. Seven hundred thirty seven – M/F=350 (47.5%)/387 (52.5%) – patients with PsA from the Russian register of PsA patients were included. Mean age 47.4±12.7 yrs., duration of PsO 200.6±158.9 mo., PsA – 79.6±81.9 mo. All patients were divided into 2 groups by PsA duration: 1st gr ≤36 mo – 288 (39.1%) and 2nd gr >36 mo – 449 (60.9%). All patients underwent standard clinical examination of PsA activity. Tender (68) and swelling (66) joint count (TJC, SJC), DAPSA, LEI, tenderness of the plantar fascia, PsO BSA (%), PASI, HAQ-DI, PsAID-12, BMI (kg/m2), ESR (mm/h), CRP (mg/l) and comorbidities by ICD-10 were evaluated. Parametric and non-parametric methods of statistical analysis were used. All p<0.05 were considered to indicate statistical significance.
Results. In patients with PsA duration >36 mo we found significant prevalence of erosions by X-Ray, axial PsA, BMI>30 kg/m2, HAQ-DI>1, PsAID-12>4, arterial hypertension, metabolic syndrome and overall comorbidity (p<0.05). There were no significant differences between groups in PsO severity by BSA>3%, PASI>1, LEI>1, TJC, SJC, dactylitis, ESR>30 mm/h, CRP>10 mg/l, DAPSA, diabetes mellitus, hyperlipidemia, coronary heart disease and liver damage (p>0.05).
Сonclusion. Long-standing stage PsA is associated with erosions, axial PsA, worst health related quality of life, functional disability and increased cardio-metabolic disorders and overall comorbidity. Our results support the idea to start bDMARDs at early stage of PsA, it can improve better outcomes.
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##article.viewOnOriginalSite##About the authors
Yulia L. Korsakova
Nasonova Research Institute of Rheumatology
Author for correspondence.
Email: yulkorsakova@bk.ru
ORCID iD: 0000-0001-5968-2403
канд. мед. наук, ст. науч. сотр. лаб. псориатического артрита ФГБНУ «НИИ ревматологии им. В.А. Насоновой»
Russian Federation, MoscowElena Yu. Loginova
Nasonova Research Institute of Rheumatology
Email: yulkorsakova@bk.ru
ORCID iD: 0000-0001-6875-4552
канд. мед. наук, ст. науч. сотр. лаб. псориатического артрита ФГБНУ «НИИ ревматологии им. В.А. Насоновой»
Russian Federation, MoscowTatiana V. Korotaeva
Nasonova Research Institute of Rheumatology
Email: yulkorsakova@bk.ru
ORCID iD: 0000-0003-0579-1131
д-р мед. наук, зав. отд. спондилоартритов и псориатического артрита ФГБНУ «НИИ ревматологии им. В.А. Насоновой»
Russian Federation, MoscowElena E. Gubar
Nasonova Research Institute of Rheumatology
Email: yulkorsakova@bk.ru
ORCID iD: 0000-0001-5015-7143
канд. мед. наук, науч. сотр. лаб. псориатического артрита ФГБНУ «НИИ ревматологии им. В.А. Насоновой»
Russian Federation, MoscowSvetlana I. Glukhova
Nasonova Research Institute of Rheumatology
Email: yulkorsakova@bk.ru
ORCID iD: 0000-0002-4285-0869
канд. мед. наук, ст. науч. сотр. лаб. медицинских и социальных проблем ФГБНУ «НИИ ревматологии им. В.А. Насоновой»
Russian Federation, MoscowElizaveta A. Vasilenko
Mechnikov North-Western State Medical University
Email: yulkorsakova@bk.ru
ORCID iD: 0000-0003-2153-5429
ассистент каф. ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»
Russian Federation, Saint PetersburgEvgeny L. Nasonov
Nasonova Research Institute of Rheumatology; Sechenov First Moscow State Medical University (Sechenov University)
Email: yulkorsakova@bk.ru
ORCID iD: 0000-0002-1598-8360
акад. РАН, д-р мед. наук, проф., науч. рук. ФГБНУ «НИИ ревматологии им. В.А. Насоновой», проф. каф. ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
Russian Federation, Moscow; MoscowReferences
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