Multicenter study of gastroesophageal reflux disease symptoms prevalence in outpatients in Russia

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Abstract

Background. Recently, there has been an increase in the prevalence of gastroesophageal reflux disease (GERD) in Northern Europe, North America and East Asia. However data on GERD prevalence in Russian population are very limited.

Aim. To determine the prevalence of GERD among the population of Russia, the clinical spectrum of GERD symptoms, the main drugs used for GERD treatment, and the rate of their administration.

Materials and methods. The study was conducted from November 2015 to January 2017 in 8 cities of Russia. A survey of patients over the age of 18 years old visiting outpatient medical institutions for any reason, including patients without gastrointestinal complaints was carried out using a short version of the Mayo Clinic questionnaire.

Results. In total, 6132 questionnaires of patients aged 18–90 years were analyzed [2456 men (40.1%) and 3676 women (59.9%), mean age – 46.6±15.4 years]. The GERD prevalence among the interviewed patients was 34.2%. The incidence of GERD increased depending on body mass index and the age of the patients. Medications used by the patients for heartburn relief included proton pump inhibitors – 59.96%, antacids – 67.92%, H2-histamine receptor blockers – 11.42%, alginates – 18.41% of patients.

Conclusion. The results of this study indicate a high prevalence of GERD among residents of Russian cities applying for primary health care (34.2%). In comparison with previous studies, an increase in the proportion of GERD patients taking proton pump inhibitors was noted; in most cases the regimen of their intake was in accordance with the recommendations.

About the authors

Dmitry S. Bordin

Loginov Moscow Clinical Scientific Center; Yevdokimov Moscow State University of Medicine and Dentistry; Tver State Medical University

Author for correspondence.
Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-2815-3992

д-р мед. наук, зав. отд. патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта ГБУЗ «МКНПЦ им. А.С. Логинова», проф. каф. пропедевтики внутренних болезней и гастроэнтерологии ФГБОУ ВО «МГМСУ им. А.И. Евдокимова», проф. каф. поликлинической терапии и семейной медицины ФГБОУ ВО ТГМУ

Russian Federation, Moscow; Moscow; Tver

Rustam А. Abdulkhakov

Kazan State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-1509-6776

д-р мед. наук, проф. каф. госпитальной терапии

Russian Federation, Kazan

Marina F. Osipenko

Novosibirsk State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-5156-2842

д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней лечебного фак-та

Russian Federation, Novosibirsk

Alla V. Solovyeva

Tver State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-7675-6889

канд. мед. наук, доц., зав. каф. общественного здоровья, организации, управления и экономики здравоохранения с учебным центром «Бережливые технологии в здравоохранении» ФГБОУ ВО ТГМУ

Russian Federation, Tver

Sayar R. Abdulkhakov

Kazan State Medical University; Kazan Federal University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-9542-3580

канд. мед. наук, доц., доц. каф. поликлинической терапии и общей врачебной практики ФГБОУ ВО «Казанский ГМУ», зав. каф. внутренних болезней, ст. науч. сотр. Института фундаментальной медицины и биологии ФГАОУ ВО КФУ

Russian Federation, Kazan; Kazan

Nikolay P. Kirilenko

Tver State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-5799-2504

д-р мед. наук, доц., проф. каф. поликлинической терапии и семейной медицины

Russian Federation, Tver

Mikhail A. Butov

Tver State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-3402-1128

д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней

Russian Federation, Tver

Olga I. Berezina

Loginov Moscow Clinical Scientific Center

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-9648-2603

канд. мед. наук, ст. науч. сотр. лаб. функциональной диагностики заболеваний пищевода и желудка

Russian Federation, Moscow

Elen R. Valitova

Loginov Moscow Clinical Scientific Center

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-3397-9748

канд. мед. наук, зав. лаб. функциональной диагностики заболеваний пищевода и желудка

Russian Federation, Moscow

Dilyara D. Safina

Kazan Federal University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-5985-3089

канд. мед. наук, мл. науч. сотр. Института фундаментальной медицины и биологии

Russian Federation, Kazan

Ilmira M. Alieva

Kazan Federal University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-5067-5848

канд. мед. наук, врач-эндоскопист медико-санитарной части

Russian Federation, Kazan

Maria A. Livzan

Omsk State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-6581-7017

д-р мед. наук, проф., зав каф. факультетской терапии и гастроэнтерологии, ректор

Russian Federation, Omsk

Aiman S. Sarsenbaeva

South Ural State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-5922-2271

д-р мед. наук, проф. каф. терапии, декан Института дополнительного профессионального образования

Russian Federation, Chelyabinsk

Galina N. Tarasova

Rostov State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-4054-9180

д-р мед. наук, проф., проф. каф. пропедевтики внутренних болезней

Russian Federation, Rostov-on-Don

Yulia V. Embutnieks

Loginov Moscow Clinical Scientific Center

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-6479-9515

д-р мед. наук, зав. отд-нием патологии верхних отделов пищеварительного тракта 

Russian Federation, Moscow

Indira R. Mubarakshina

Kazan Federal University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-3978-0430

лаборант-исследователь Института фундаментальной медицины и биологии

Russian Federation, Kazan

Ilshat Kh. Khayrullin

Kazan Federal University

Email: d.bordin@mknc.ru

канд. мед. наук, преподаватель Института фундаментальной медицины и биологии

Russian Federation, Kazan

Alla G. Kononova

Tver State Medical University

Email: d.bordin@mknc.ru

канд. мед. наук, доц. каф. поликлинической терапии и семейной медицины

Russian Federation, Tver

Sergey V. Kolbasnikov

Tver State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-9223-0457

д-р мед. наук, проф., зав. каф. поликлинической терапии и семейной медицины

Russian Federation, Tver

Igor V. Maev

Yevdokimov Moscow State University of Medicine and Dentistry

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-6114-564X

акад. РАН, д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней и гастроэнтерологии

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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2. Fig. 1. The proportion of patients with gastroesophageal reflux dise (GERD) among the respondents of different age groups.

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3. Fig. 2. Dependence of the presence of symptoms of GERD (frequent heartburn/regurgitation) on the age of the respondents.

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4. Fig. 3. Distribution of patients with GERD, episodic heartburn/regurgitation, without symptoms in groups with different body mass inde (BMI).

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5. Fig. 4. Frequency of symptoms of GERD (heartburn/regurgitation) once a week or more, depending on BMI.

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6. Fig. 5. The frequency of taking antacids and proton pump inhibitors (PPIs), depending on the age of the respondents and BMI.

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7. Fig. 6. Frequency of PPIs use in a group of GERD patients (with frequent heartburn and/or regurgitation).

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8. Fig. 7. Prescribing PPIs to GERD patients (with frequent heartburn and/or regurgitation).

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