Photosensitizing Activity of Steroid Derivatives of Pyropheophorbide in the Oxidation of Tryptophan in the Aqueous Phase
- Authors: Solov’eva A.B.1, Kur’yanova A.S.1, Savko M.A.1, Aksenova N.A.1,2, Afanas’evskaya E.V.2, Zolottsev V.A.3, Taratynova M.O.3, Ponomarev G.V.3, Timashev P.S.2,4
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Affiliations:
- Semenov Institute of Chemical Physics, Russian Academy of Sciences
- Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
- Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences
- Crystallography and Photonics Federal Research Center, Russian Academy of Sciences
- Issue: Vol 92, No 9 (2018)
- Pages: 1830-1836
- Section: Photochemistry and Magnetochemistry
- URL: https://journals.rcsi.science/0036-0244/article/view/170139
- DOI: https://doi.org/10.1134/S0036024418090261
- ID: 170139
Cite item
Abstract
Solubilization with pluronic F-127 gave water-soluble forms of hydrophobic photosensitizers—steroid derivatives of pyropheophorbide a. Solubilization was performed by evaporating the chloroform co-solutions of photosensitizer and pluronic (triple block copolymer of ethylene and propylene oxide) and subsequently dissolving the resulting dry residue in water. The concentration ratios of modified pyropheophorbide–pluronic at which the photosensitizer completely passed into the aqueous phase were determined. Among the starting hydrophobic photosensitizers, pyropheophorbide–dihydrotestosterone possessed the highest activity in photosensitized oxidation of anthracene with singlet oxygen in chloroform, while after solubilization, pyropheophorbide–testosterone was most active in the test (for photodynamic therapy) oxidation of tryptophan in aqueous solutions.
About the authors
A. B. Solov’eva
Semenov Institute of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow, 119991
A. S. Kur’yanova
Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow, 119991
M. A. Savko
Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow, 119991
N. A. Aksenova
Semenov Institute of Chemical Physics, Russian Academy of Sciences; Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow, 119991; Moscow, 119991
E. V. Afanas’evskaya
Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow, 119991
V. A. Zolottsev
Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow
M. O. Taratynova
Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow
G. V. Ponomarev
Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow
P. S. Timashev
Institute of Regenerative Medicine, Sechenov First Moscow State Medical University; Crystallography and Photonics Federal Research Center, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Russian Federation, Moscow, 119991; Moscow