Photosensitizing Activity of Steroid Derivatives of Pyropheophorbide in the Oxidation of Tryptophan in the Aqueous Phase
- Autores: Solov’eva A.1, Kur’yanova A.1, Savko M.1, Aksenova N.1,2, Afanas’evskaya E.2, Zolottsev V.3, Taratynova M.3, Ponomarev G.3, Timashev P.2,4
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Afiliações:
- Semenov Institute of Chemical Physics, Russian Academy of Sciences
- Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
- Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences
- Crystallography and Photonics Federal Research Center, Russian Academy of Sciences
- Edição: Volume 92, Nº 9 (2018)
- Páginas: 1830-1836
- Seção: Photochemistry and Magnetochemistry
- URL: https://journals.rcsi.science/0036-0244/article/view/170139
- DOI: https://doi.org/10.1134/S0036024418090261
- ID: 170139
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Resumo
Solubilization with pluronic F-127 gave water-soluble forms of hydrophobic photosensitizers—steroid derivatives of pyropheophorbide a. Solubilization was performed by evaporating the chloroform co-solutions of photosensitizer and pluronic (triple block copolymer of ethylene and propylene oxide) and subsequently dissolving the resulting dry residue in water. The concentration ratios of modified pyropheophorbide–pluronic at which the photosensitizer completely passed into the aqueous phase were determined. Among the starting hydrophobic photosensitizers, pyropheophorbide–dihydrotestosterone possessed the highest activity in photosensitized oxidation of anthracene with singlet oxygen in chloroform, while after solubilization, pyropheophorbide–testosterone was most active in the test (for photodynamic therapy) oxidation of tryptophan in aqueous solutions.
Sobre autores
A. Solov’eva
Semenov Institute of Chemical Physics, Russian Academy of Sciences
Autor responsável pela correspondência
Email: anna@polymer.chph.ras.ru
Rússia, Moscow, 119991
A. Kur’yanova
Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Rússia, Moscow, 119991
M. Savko
Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Rússia, Moscow, 119991
N. Aksenova
Semenov Institute of Chemical Physics, Russian Academy of Sciences; Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
Email: anna@polymer.chph.ras.ru
Rússia, Moscow, 119991; Moscow, 119991
E. Afanas’evskaya
Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
Email: anna@polymer.chph.ras.ru
Rússia, Moscow, 119991
V. Zolottsev
Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Rússia, Moscow
M. Taratynova
Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Rússia, Moscow
G. Ponomarev
Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Rússia, Moscow
P. Timashev
Institute of Regenerative Medicine, Sechenov First Moscow State Medical University; Crystallography and Photonics Federal Research Center, Russian Academy of Sciences
Email: anna@polymer.chph.ras.ru
Rússia, Moscow, 119991; Moscow