Calendula officinalis (Asteraceae) as a radiosensitizer in radiotherapy of tumors
- Authors: Koldman S.D.1, Koldman V.A.1,2, Belousov A.V.2, Mazaletskaya L.I.3
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Affiliations:
- Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency
- Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency
- Emanuel Institute of Biochemical Physics of Russian Academy of Sciences
- Issue: Vol 60, No 1 (2024)
- Pages: 112-124
- Section: Biological Activity of Resource Species
- URL: https://journals.rcsi.science/0033-9946/article/view/258205
- DOI: https://doi.org/10.31857/S0033994624010089
- EDN: https://elibrary.ru/HAAVMG
- ID: 258205
Cite item
Abstract
The effect of aqueous-alcoholic tincture of Сalendula officinalis L. (Asteraceae) on tumor cells of different species and tissue origin was studied. Its potential as a radiosensitizer in combination with γ-radiation was determined. It has been established that C. officinalis tincture causes the death of tumor cells regardless of their p53 and p21 status. C. officinalis tincture has antioxidant properties, but for cells with active p21 it exhibits radiosensitizing rather than radioprotective properties. For cells lacking p21, C. officinalis tincture is a radioprotector, so the cell death is p21 mediated. A study of the radiosensitizing properties of C. officinalis was carried out on a mouse melanoma model in vivo. In combination with γ-radiation, it led to a significant inhibition of tumor growth (by 47%), as compared to irradiation only. The significant radiosensitizing effect and capability of overcoming the tumor cells resistance induced by p53 inactivation make C. officinalis tincture promising as an add-on to radiotherapy, allowing to reduce the effective radiation dose 1.7 times.
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About the authors
S. D. Koldman
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency
Author for correspondence.
Email: epistularum@yandex.ru
Russian Federation, Moscow
V. A. Koldman
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency; Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency
Email: epistularum@yandex.ru
Russian Federation, Moscow; Moscow
A. V. Belousov
Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency
Email: epistularum@yandex.ru
Russian Federation, Moscow
L. I. Mazaletskaya
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences
Email: epistularum@yandex.ru
Russian Federation, Moscow
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