The Genus Iris (Iridaceae) in Russia: Phytochemistry, Biological Activity and Application in Traditional Medicine
- Authors: Alexeeva N.B.1, Dorofeeva M.M.2, Varfolomeeva E.A.1, Mironova L.N.3
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Affiliations:
- Komarov Botanical Institute, RAS
- Saint Petersburg State Forest Technical University
- Botanical Garden-Institute Far Eastern Branch of the Russian Academy of Sciences
- Issue: Vol 59, No 1 (2023)
- Pages: 3-29
- Section: ОБЗОР
- URL: https://journals.rcsi.science/0033-9946/article/view/138761
- DOI: https://doi.org/10.31857/S003399462301003X
- EDN: https://elibrary.ru/XXHBZX
- ID: 138761
Cite item
Abstract
The genus Iris in Russia is represented by 41 species, of which 4 species are endemic, 11 are included in the Red Book of the Russian Federation and 30 have various regional conservation status. The review provides information on the phytochemical compounds, biological activity and medicinal properties of 16 species growing in Russia, and on their use in traditional medicine of different peoples. The analysis of available data shows that studying the component composition, biological activity levels, and medicinal use of Iris L. species requires their correct identification and the knowledge concerning their geographical distribution, ecology, and morphological characteristics. The use of Iris species in traditional medicine is described. The extracts and compounds isolated from the most of the studied species exhibit analgesic, antioxidative, antipyretic, anti-inflammatory, antibacterial and antimicrobial activity. Some species also have cytotoxic, antitumor, antidiabetic, anti-influenza, neuroprotective, antihyperglycemic, antiallergic, antifeedant and other properties. Most of the isolated metabolites were flavonoids, isoflavonoids, anthocyanes, terpenoids, xantgones, quinones, phenolic and fatty acids. In official and traditional medicine in Asia and Europe, the underground and aboveground parts of Iris aphylla, I. lactea, I. pseudacorus, I. ruthenica, I. sanguinea and other species of the genus are used. The article results from the long-term studies of irises in situ and in the collections of two botanical gardens, as well as extensive examination of literature on the component composition and medicinal properties of the studied species.
About the authors
N. B. Alexeeva
Komarov Botanical Institute, RAS
Email: drofa88@mail.ru
Russia, Saint-Petersburg
M. M. Dorofeeva
Saint Petersburg State Forest Technical University
Author for correspondence.
Email: drofa88@mail.ru
Russia, Saint-Petersburg
E. A. Varfolomeeva
Komarov Botanical Institute, RAS
Email: drofa88@mail.ru
Russia, Saint-Petersburg
L. N. Mironova
Botanical Garden-Institute Far Eastern Branch of the Russian Academy of Sciences
Email: drofa88@mail.ru
Russia, Vladivostok
References
- Mathew B. 1981. The Iris. London. 202 p.
- Rodionenko G.I. 1987. The genus Iris L. (questions of morphology biology, evolution and systematics). London. 222 p.
- Alexeeva N.B. 2020. Iris L. (Iridaceae Juss.) in Russia. Saint-Petersburg. 232 p. (In Russian, English)
- Purev O., Purevsuren C., Narantuya S., Lkhagvasuren S., Mizukami H., Nagatsu A. 2002. New isoflavones and flavanol from Iris potaninii. – Chem. Pharm. Bull. (Tokyo). 50(10): 1367–1369. https://doi.org/10.1248/cpb.50.1367
- Kaššák P. 2012. Secondary metabolites of the chosen genus Iris species. – Acta Univ. Agric. Silvic. Mendelianae Brun. 60(8): 32. https://doi.org/10.11118/actaun201260080269
- Mykhailenko O., Kovalyov V., Kovalyov S., Toryanik E., Osolodchenko T., Buidin Y. 2017a (2018). Fatty acid composition of lipids of Iris sibirica. – Čes. slov. Farm. 66(5): 220–226. https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2017-5-7/fatty-acid-composition-of-lipids-of-iris-sibirica-63385
- Thunberg C.P. 1794. Botanical observation on the flora Japonica. – Trans. Linn. Soc. Lond. 2: 326–342. https://doi.org/10.1111/j.1096-3642.1794.tb00268.x
- Grubov V.I. 1970. [Critical Remarks on the taxonomy and nomenclature of some species of iris. Flora of the USSR]. – Novitates systematicae plantarum vascularium. 6: 29–37. (In Russian)
- Schroeter A.I. 1975. [Medicinal flora of the Soviet Far East]. Moscow. 328 p. (In Russian) https://www.booksite.ru/fulltext/rusles/lekflora/index.htm
- Bunge A.A. 1833. Enumeratio plantarum, quas in China boreali collegit Dr. Al. Bunge: Anno 1831. St. Petersburg. 79 p.
- Blinova K.F., Stukkey K.L. 1960. [Pharmacognostic study of the medicinal plants in Tibetan medicine: I]. – In: [Trudy Leningradskogo Khimiko-Farmatsevticheskogo Instituta. Voprosy Farmakognozii. 1]. Vol. 12. Leningrad. P. 135–155. (In Russian)
- Blinova K.F., Stukkey K.L. 1964. [Pharmacognostic study of the medicinal plants in Tibetan medicine: II]. – In: [Trudy Leningradskogo Khimiko-Farmatsevticheskogo Instituta. Voprosy Farmakognozii. 2]. Vol. 17. Leningrad. 173–190. (In Russian)
- Blinova K.F., Kalyupanova N.I. 1974. Xanthone glycosides of Iris ensata. – Chem. Nat. Compd. 10(4): 551. https://doi.org/10.1007/BF00563849
- Blinova K.F., Glyzin V.I., Pryakhina N.I. 1977. A C glycoside from Iris ensata. – Chem. Nat. Compd. 13(1): 104. https://doi.org/10.1007/BF00566189
- Pryakhina N.I., Blinova K.F. 1979. Phenolic acids of Iris ensata. – Chem. Nat. Compd. 15: 768. https://doi.org/10.1007/BF00565598
- Pryakhina N.I., Blinova K.F. 1984. Luteolin C-glycosides from Iris ensata. – Chem. Nat. Compd. 20(1): 107. https://doi.org/10.1007/BF00574811
- Pryakhina N.I., Sheichenko V.I., Blinova K.F. 1984. Acylated C-glycosides of Iris lactea. – Chem. Nat. Compd. 20(5): 554–559. https://doi.org/10.1007/BF00580064
- [Plant Resources of Russia and neighboring states: Flowering plants, their chemical composition, use. Vol. 8. (Family Butomaceae – Typhaceae)]. 1994. Saint-Petersburg. 272 p. (In Russian)
- [Plant Resources of Russia: Wild-growing flowering plants, their component composition and biological activity. Vol. 6. (Family Butomaceae – Typhaceae)]. 2014. Saint-Petersburg. 391 p. (In Russian)
- Tikhomirova L.I., Bazarnova N.G., Mikushina I.V., Dolganova Z.V. 2015. Farmacol-biochemical study of practical use of some members of the genus Iris L. (Overview). – Khimija rastitel’nogo syr’ja. 3: 25–34. (In Russian)https://doi.org/10.14258/jcprm.201503837
- WFO: Iris lactea Pall. 2023. http://www.worldfloraonline.org/taxon/wfo-0000783525
- WFO: Iris oxypetala Bunge. 2023. http://www.worldfloraonline.org/taxon/wfo-0000790813
- Varlakov M.N. 1933. [East Sayan Expedition NIHFI (Scientific Research Chemical and Pharmaceutical Institute)]. – Khimiko-Farmatsevticheskaya Promyshlennost. 3: 154–157. (In Russian)
- Varlakov M.N. 1963. [List of plants of Eastern Transbaikalia used in Tibetan medicine]. – In: [Selected Works]. Moscow. P. 122–169. (In Russian)
- Pryakhina N.I. 1984. [Phytochemical study of milky iris. – Iris lactea Pall.: Diss. … Cand. (Pharmacology) Sci.] Leningrad. 193 p. (In Russian)
- Minina S.A., Abu Skhela G.R.I., Astakhova T.V., Pryakhina N.I., Zenkevich I.G., Kosman V.M. 1999. Technology of dry extract production from the above-ground part of milk-white Iris herbs (Iris lactea Pall.) – Pharm. Chem. J. 3(4): 211–213. https://doi.org/10.1007/BF02509942
- Haidav Ts., Altanchimeg B., Varlamova T.S. 1985. [Medicinal plants in Mongolian medicine]. 2nd ed. Ulaanbaatar. 391 p. (In Russian)
- Li D.-X., Hao X.-G., Zhang S.-K., Wang S.-X., Liu R.-Y., Ma K.-S., Yu S.-P., Jiang H., Guan J.-F. 1981. Antitumor action and toxicity of 6-methoxy-2-delta10’-cis-heptadecenyl-1,4-benzoquinone (irisquinone). – Acta Pharmacol. Sin. 2(2): 131–134. http://www.chinaphar.com/article/view/4132 (In Chinese with English summary)
- Han J. 1988. Traditional Chinese medicine and the search for new antineoplastic drugs. – J. Ethnopharmacol. 24(1): 1–17. https://doi.org/10.1016/0378-8741(88)90135-3
- Han R. 1994. Highlight on the studies of anticancer drugs derived from plants in China. – Stem Cells. 12(1): 53–63. https://doi.org/10.1002/stem.5530120110
- Wang X.W. 1999. Irisquinone: Antineoplastic, radiosensitizer. – Drugs Future. 24: 613–617. https://doi.org/10.1358/dof.1999.024.06.538308
- Chen D., Meng Y., Zhu Y., Wu G., Yuan J., Qin M., Xie G. 2018. Qualitative and Quantitative Analysis of C-glycosyl-flavones of Iris lactea Leaves by Liquid Chromatography/Tandem Mass Spectrometry. – Molecules. 23(12): 3359. https://doi.org/10.3390/molecules23123359
- Zang J., Xia G., Liu X. 1983. Physicochemical properties of Ma Lin Zi (seed of Iris pallasii) oil and identification of its fatty acids. – Chinese traditional and herbal drugs (Zhong cao yao). 14(3): 103–105. (In Chinese)
- Minina S.A., Pryakhina N.I., Chemesova I.I., Chizhikov D.V. 2008. Medicinal preparation from Iris lactea for children. – Khimiko-Farmatsevticheskii Zhurnal. 42(1): 39–41. http://chem.folium.ru/index.php/chem/article/view/429 (In Russian)
- Kim J.L., Li H.M., Kim Y.H., Lee Y.J., Shim J.H., Lim S.S., Kang Y.H. 2012. Osteogenic activity of yellow flag iris (Iris pseudacorus) extract modulating differentiation of osteoblasts and osteoclasts. – Am. J. Chin. Med. 40(6): 12891305. https://doi.org/10.1142/S0192415X12500954
- Levchuk A.P. 1927. [Hemostatic and uterine agents]. – Bulletin Khimiko-Faramtsevticheskogo NII. 15: 3–79. (In Russian)
- Chopik V.I., Dudchenko L.G., Krasnova A.N. 1983. [Wild useful plants of Ukraine]. Kyiv. 400 p. (In Russian)
- Chikov P.S. 1989. [Medicinal plants]. 2nd ed. Moscow. 431 p. (In Russian)
- Tikhomirova E.A., Sorokina A.A., Bubenchikova V.N., Kostikova E.N., Zhilkina V.Yu., Bessonov V.V. 2020. Chemical Composition and Content of Polysaccharides from the Yellow Iris (Iris pseudacorus L.) Rhizomes. – Pharmacogn. J. 12(5): 1012–1018. https://doi.org/10.5530/pj.2020.12.143
- Kashin N.I. 1860. [Home-made medication remedies used by Cis-Argun population, and Cis-Argun folk doctors]. – Bulletin of the Russian Geographical Society. 30(11): 121–145. https://elib.rgo.ru/safe-view/123456789/218937/1/0L8tMTA0NTZfdmVzdG5pa1JHT18zMGNoXzE4NjAucGRm (In Russian)
- Deriker V. 1866. [Collection of folk remedies used by healers in Russia]. Saint Petersburg. 258 p. https://www.travolekar.ru/arch/Deriker_1866.pdf (In Russian)
- Gammerman A.F., Semichov B.V. 1963. [Dictionary of Tibetan-Latin-Russian names of medicinal plant materials used in Tibetan medicine]. Ulan-Ude. 108 p. (In Russian)
- Vostrikova G.G., Vostrikov P.A. 1971. [Medicine of the Dersu people]. Khabarovsk. 37 p. (In Russian)
- Chopra R.N., Nayar S.L., Chopra J.C. 1956. Glossary of Indian medicinal plants. New Delhi. 174 p.
- Sugawara S. 1937. [Plants of Saghalien]. Toyohara. 490 p. (In Japanese)
- Efremova N.A. 1967. Medicinal plants of Kamchatka and the Commander Islands. Petropavlovsk-Kamchatsky. 123 p. (In Russian)
- Semichov B.V. 1958. [On some herbal products of Indo-Tibetan medicine growing in the Buryat-Mongolian ASSR]. – In: [Local studies of the Buryat-Mongolian branch of the Geographical Society of the USSR]. Issue. 2. Ulan-Ude. P. 158–162. (In Russian)
- Bondarenko A.S., Aizenman B.E., Shvaiger M.O., Mandrik T.P., Bredikhina A.N. 1964. [Antimicrobial activity of some plants]. – [Phytoncides in the national economy]. Kyiv. P. 170–179. (In Russian)
- Poroshina G.I. 1964. [Influence of some plant antibiotics on lactic acid bacteria]. – [Phytoncides in the national economy]. Kyiv. P. 146–153. (In Russian)
- Mykhailenko O., Korinek M., Ivanauskas L., Bezruk I., Myhal A., Petrikaitė V., El-Shazly M., Lin G.-H., Lin C.-Y., Yen C.-H., Chen B.-H., Georgiyants V., Hwang T.-L. 2020. Qualitative and Quantitative Analysis of Ukrainian Iris Species: A Fresh Look on Their Antioxidant Content and Biological Activities. – Molecules. 25(19): 4588. https://doi.org/10.3390/molecules25194588
- Annenkov N.I. 1878. [Botanical Dictionary]. 2nd ed. Saint Petersburg. 645 p. (In Russian)
- Petrusheva N.I. 1957. [Fungicidal properties of higher plants]. – Bulletin Nauchno-tekhnicheskoy Informatsii Nikitskogo Botanicheskogo Sada. 2: 41–46. (In Russian)
- [“Dzeitshar Migzhan” – the monument of Tibetan medicine]. 1985. Novosibirsk. 88 p. (In Russian)
- [Plants of Tibetan medicine: the pharmacognostic research experience]. 1989. Novosibirsk. 159 p. (In Russian)
- Hegnauer R. 1963. Chemotaxonomie der Pflanzen. Monocotyledonene. B. 2. 540 p. https://doi.org/10.1007/978-3-0348-9387-9
- Ishikura N. 1980. Anthocyanins in iris flowers. – Experientia. 36(6): 656–657. https://doi.org/10.1007/BF01970120
- Harborne J.B., Mabry T.J. 1982. The Flavonoids: advances in research. 744 p. https://doi.org/10.1007/978-1-4899-2915-0
- Yabuya T., Yokota K., Adachi T., Nagatomo T. 1983. High-performance liquid chromatographic separation of anthocyanins in the flowers of Iris ensata Thunb. – Bulletin Faculty of Agriculture University of Miyazaki. 30(1): 7–13. (In Japanese with English summary)
- Yabuya T., Nakamura M., Iwashina T., Yamaguchi M., Takehara T. 1997. Anthocyanin-flavone copigmentation in bluish purple flowers of Japanese garden iris (Iris ensata Thunb). – Euphytica. 98(3): 163–167. https://doi.org/10.1023/A:1003152813333
- Kojima K., Gombosurengyin P., Ondogyni P., Begzsurengyin D., Zevgeegyin O., Hatano K., Ogihara Y. 1997. Flavanones from Iris tenuifolia. – Phytochemistry. 44(4): 711–714. https://doi.org/10.1016/S0031-9422(96)00596-1
- Choudhary M.I., Hareem S., Siddiqui H., Anjum S., Ali S., Atta-Ur-Rahman, Zaidi M.I. 2008. A benzil and isoflavone from Iris tenuifolia. – Phytochemistry. 69(9): 1880–1885. https://doi.org/10.1016/j.phytochem.2008.03.011
- Wang H., Cui Y., Zhao C. 2010. Flavonoids of the Genus Iris (Iridaceae). – Mini Rev. Med. Chem. 10(7): 643–661. https://doi.org/10.2174/138955710791384027
- Kovalev V.N., Zatyl’nikova O.A., Kovalev S.V. 2013a. A New Isoflavone from Iris pseudacorus. – Chem. Nat. Compd. 49(1): 34–35. https://doi.org/10.1007/s10600-013-0499-y
- Kukula-Koch W., Sieniawska E., Widelski J., Urjin O., Głowniak P., Skalicka-Woźniak K. 2015. Major secondary metabolites of Iris spp. – Phytochem. Rev. 14(1): 51–80. https://doi.org/10.1007/s11101-013-9333-1
- Wani S.H., Lon S.A., Mustafa M.F., Mir J.I., Qadri R.I., Hassan Q.P. 2017. Evaluation of prominent isoflavonoids of Iris plant as futuristic cancer drug components. – Int. J. Botany Stud. 2(1): 129–134. http://www.botanyjournals.com/archives/2017/vol2/issue1/3-3-45
- Zagorulko E.Yu., Ozhigova M.G., Chemesova I.I., Luzhanin V.G. 2018. Quantification of total flavonoid content in the aerial part and in the tincture of Iris lactea (Iridaceae). – Khimija rastitel’nogo syr’ja. 2: 105–113. https://doi.org/ (In Russian)https://doi.org/10.14258/jcprm.2018023368
- Iwashina T., Mizuno T. 2020. Flavonoids and Xanthones From the Genus Iris: Phytochemistry, Relationships with Flower Colors and Taxonomy, and Activities and Function. – Nat. Prod. Commun. 15(10): 1934578X2093715. https://doi.org/10.1177/1934578X20937151
- Bate-Smith E.C. 1968. The phenolic constituents of plants and their taxonomic significance: II. Monocotyledons. – Bot. J. Linn. Soc. 60(383): 325–356. https://doi.org/10.1111/j.1095-8339.1968.tb00094.x
- Denisova O.A., Glyzin V.I., Patudin A.V., Gavrilenko B.D. 1980. Determination of xanthone glycoside mangiferin content in Iris, Gentiana and Hedysarum species. – Khimiko-Farmatsevticheskii Zhurnal. 14(12): 76–77. (In Russian)
- Williams C.A., Harborne J.B. 1985. Biflavonoids, Quinones and Xanthones as Rare Chemical Markers in the Family Iridaceae. – Zeitschrift Für Naturforschung C. 40(5–6): 325–330. https://doi.org/10.1515/znc-1985-5-608
- Williams C.A., Harborne J.B., Goldblatt P. 1986. Correlations between phenolic patterns and tribal classification in the family Iridaceae. – Phytochemistry. 25(9): 2135–2154. https://doi.org/10.1016/0031-9422(86)80079-6
- Brooks C.J.W., Watson D.G. 1985. Phytoalexins. – Natural Product Reports. 2(5): 427–459. https://doi.org/10.1039/np9850200427
- Hoang L., Beneš F., Fenclová M., Kronusová O., Švarcová V., Řehořová K., Baldassarre Švecová E., Vosátka M., Hajšlová J., Kaštánek P., Viktorová J., Ruml T. 2020. Phytochemical Composition and In Vitro Biological Activity of Iris spp. (Iridaceae): A New Source of Bioactive Constituents for the Inhibition of Oral Bacterial Biofilms. – Antibiotics. 9(7): 403. https://doi.org/10.3390/antibiotics9070403
- Machalska A., Skalicka-Woźniak K., Widelski J., Głowniak K., Purevsuren G., Oyun Z., Khishgee D., Urjin B. 2008. Screening for phenolic acids in five species of Iris collected in Mongolia. – Acta Chromatogr. 20(2): 259–267. https://doi.org/10.1556/AChrom.20.2008.2.10
- Pryakhina N.I., Blinova K.F. 1987. Swertiajaponin from Iris lactea. – Chem. Nat. Compd. 23(2): 257–258. https://doi.org/10.1007/BF00598780
- Whaley A.K., Ebrahim W., El-Neketi M., Ancheeva E. 2017. New acetylated flavone C-glycosides from Iris lactea. – Tetrahedron Lett. 58(22): 2171–2173. https://doi.org/10.1016/j.tetlet.2017.04.080
- Chang N., Luo Z., Li D., Song H. 2017. Indigenous Uses and Pharmacological Activity of Traditional Medicinal Plants in Mount Taibai, China. – Evid.-Based Complementary Altern. Med. 1–11. https://doi.org/10.1155/2017/8329817
- Dragendorff G. 1898. Die Heilpflanzen der verschiedenen Völker und Zeiten. Ihre Anwendung, wesentlichen Bestandteile und Geschichte. Stuttgart. 885 p.
- Chaurasia O.P., Singh B. 2000. An Ethnobotanical Profile on Cold Desert Flora of Nubra Valley (Ladakh). – Bull. Bot. Surv. India. 42: 81–90. https://doi.org/ https://nelumbo-bsi.org/index.php/nlmbo/article/view/74263/0https://doi.org/10.20324/nelumbo/v42/2000/74263
- Haq S.M., Yaqoob U., Calixto E.S., Rahman I.U., Hashem A., Abd Allah E.F., Alakeel M.A., Alqarawi A.A., Abdalla M., Hassan M., Bussmann R.W., Abbasi A.M., Ur Rahman S., Ijaz F. 2021. Plant Resources Utilization among Different Ethnic Groups of Ladakh in Trans-Himalayan Region. – Biology (Basel). 10(9): 827. https://doi.org/10.3390/biology10090827
- Melnikova T.I. 1994. [Pharmacological study of the crude extract of milky iris (Iris lactea Pall.): Abstr. … Diss. Cand. (Biology) Sci.]. Saint Petersburg. 20 p. (In Russian)
- Pastushenkov L.V., Barinov V.A., Frolova N.Yu. et al. 1995. [A new immunomodulatory drug – an extract of milky iris]. – In: [Abstracts of the scientific-practical conference dedicated to the 280th anniversary of the First Naval Hospital “Actual Issues of Naval and Clinical Medicine”]. Saint Petersburg. 205 p. (In Russian)
- Melnikova T.I., Frolova N.Yu. 1996. [Possibilities of using the drug lactir in chronic renal failure]. – In: [Actual problems of creating new drugs: Proc. of the All-Russian scientific conference]. Saint Petersburg. P. 147. (In Russian)
- Frolova N.Yu., Melnikova T.I., Placen R.I. 1992. [Pharmacological evaluation of the polyextract of Iris lactea]. – In: [Abstracts of the 3rd Ukrainian Conference on Medical Botany:]. Part 1. Kyiv. 139 p. (In Russian)
- Gamal R. 1996. [Technology and analysis of tableted dry extract of milky iris (Iris lactea Pall.): Abstr. … Diss. Cand. (Pharmacology) Sci.]. Saint Petersburg. 21 p. (In Russian)
- Aroyan M.V., Kaukhova I.E., Goncharova S.B. 2017. Determination of merchandising parameters of Iris lactea crude sample. – Research results in biomedicine. 3(4): 17–20. (In Russian)https://doi.org/10.18413/2313-8955-2017-3-4-17-20
- Luzhanin V.G., Whaley A.K., Ponkratova A.O., Zhokhova E.V., Zingalyuk M.A., Pryaknina N.I. 2021. Iris milky-white (Iris lactea Pall.) – a promising source of biologically active substances. – Khimija rastitel’nogo syr’ja. 3: 5–17. (In Russian)https://doi.org/10.14258/jcprm.2021038890
- Astakhova T.V., Pryakhina N.I., Minina S.A., Ismailov G.R. 1994. [On the issue of obtaining and analyzing a dry extract of Iris lactea Pall.]. – In: [Solving urgent problems of pharmacy at the present stage: Abstracts of the scientific conference dedicated to the 50th anniversary of the Research Institute of Pharmacy]. Moscow. 240 p. (In Russian)
- Bychkova N.V., Kalashnikova A.A., Waley A.K., Luzhanin V.G., Kalinina N.M., Shustov E.B., Okovity S.V. 2019. [Study of the immunotropic effects of flavone glycoside embinin by flow cytometry]. – Preventive and Clinical Medicine. 4(73): 77–82. https://profclinmed.szgmu.ru/PIK_4-2019.pdf (In Russian)
- Astakhova T.V., Pryakhina N.I., Lanina N.E., Zazhigalkina M.V., Chemesova I.I. 2000. [Development of the method for standardizing the syrup with the milk-white iris extract]. – In: [Actual problems of pharmaceutical science and education: Mat. of scientific conf.]. P. 170–171. (In Russian)
- Lanina N.E. 2003. [Development of technologies for tincture from Iris lactea Pall. grass and its standardization: Abstr. … Diss. Cand. (Pharmacology). Sci.]. Saint Petersburg. 2003. 23 p. (In Russian)
- Luan Z., Li P., Li D., Meng X., Sun J. 2020. Optimization of Supercritical-CO2 extraction of Iris lactea Seed Oil: Component Analysis and Antioxidant Activity of the Oil. – Ind. Crops Prod. 112553. https://doi.org/10.1016/j.indcrop.2020.112553
- Seki K., Haga K., Kaneko R. 1995. Phenols and a dioxotetrahydrodibenzofuran from seeds of Iris pallasii. – Phytochemistry. 38(4): 965–973. https://doi.org/10.1016/0031-9422(94)00731-8
- Wu Sh.-Ch., Chang L., Yang H.-H., Li T.-Y. 1980. Isolation and structural studies of pallasone B and pallasone C. – Yao Hsueh T’ung Pao. 15(8): 43; Chem. Abstrs. 1981. 95: 86202.
- Zhou J., Xie G., Yan X. 2011. Encyclopedia of traditional Chinese medicines molecular structures, pharmacological activities, natural sources and applications. Vol. 4. Isolated compounds N–S. 636 p. https://doi.org/10.1007/978-3-642-16779-9
- Wu S.J., Yang Q.Z. 1981. Chemical studies on Iris pallasii Fisch. var. chinensis Fisch. II. The isolation and structure studies of pallasone B and pallasone C. – Acta Chim. Sinica 39: 767–770.
- Lv H., Yuan Z., Wang X., Wang Z., Suo Y., Wang H. 2015. Rapid separation of three proanthocyanidin dimers from Iris lactea Pall. var. chinensis (Fisch.) Koidz by high-speed counter-current chromatography with continuous sample load and double-pump balancing mode. – Phytochem. Anal. 26(6): 444–453. https://doi.org/10.1002/pca.2579
- Lv H., Ouyang J., Wang X., Ma X., Suo Y., Wang H. 2015. Separation and Purification of Four Flavan-3-ols From Iris lactea Pall. var. chinensis (Fisch.) Koidz by High-Speed Counter-Current Chromatography with Flow-Rate Gradient. – J. Liq. Chromatogr. Relat. Technol. 38(15): 1486–1493. https://doi.org/10.1080/10826076.2015.1063506
- Kim H.W., Kim S.S., Kang K.B., Ryu B., Park E., Huh J., Jeon W.K., Chae H.-S., Oh W.K., Kim J., Sung S.H., Chin Y.-W. 2020. Combined MS/MS-NMR Annotation Guided Discovery of Iris lactea var. chinensis Seed as a Source of Viral Neuraminidase Inhibitory Polyphenols. – Molecules. 25(15): 3383. https://doi.org/10.3390/molecules25153383
- Tie F., Wang J., Liang Y., Zhu S., Wang Z., Li G., Wang H. 2020a. Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function. – Int. J. Mol. Sci. 21(6): 2029. https://doi.org/10.3390/ijms21062029
- Lv H., Wang H., He Y., Ding C., Wang X., Suo Y. 2015a. Separation and purification of four oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz by high-speed counter-current chromatography. – J. Chromatogr. B. 988: 127–134. https://doi.org/10.1016/j.jchromb.2015.02.035
- Wang X., Jiang B., Lv H., Liang Y., Ma X. 2019. Vitisin B as a novel fatty acid synthase inhibitor induces human breast cancer cells apoptosis. – Am. J. Transl. Res. 11(8): 5096–5104. https://e-century.us/files/ajtr/11/8/ajtr0091295.pdf
- Tie F.F., Luan G.X., Zhou W.N., Wang Z.H., Shi X.B., Li G., Wang H.L. 2018. Effects of the oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz on the adipocytes differentiation of 3T3-L1 cells. – Pharmazie. 73(2): 98–103. https://doi.org/10.1691/ph.2018.7844
- Tie F., Li G., Hu N., Li J., Wang Z., Wang H. 2020b. Oligostilbenes extracts from Iris lactea Pall. var. chinensis (Fisch.) Koidz improve lipid metabolism in HFD/STZ-induced diabetic mice and inhibit adipogenesis in 3T3-L1 cells. – Biomed. Pharmacother. 131: 110800. https://doi.org/10.1016/j.biopha.2020.110800
- Lv H., Zhou W., Wang X., Wang Z., Suo Y., Wang H. 2016. Extraction and Separation of Vitisin D, Ampelopsin B and cis-Vitisin A from Iris lactea Pall. var. chinensis (Fisch.) Koidz by Alkaline Extraction-Acid Precipitation and High-Speed Counter-Current Chromatography. – J. Chromatogr. Sci. 54(5): 744–751. https://doi.org/10.1093/chromsci/bmv249
- Tie F.F., Fu Y.Y., Hu N., Chen Z., Wang H.L. 2022. Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities. – RSC Adv. 12(51): 32912–32922. https://doi.org/10.1039/D2RA05176A
- Wang X., Qin M.J., Li L., Ye W.C. 2005. Chemical Constituents of Underground Parts of Iris lactea. – J. Chi. Pharm. Univ. 36: 517–519. https://doi.org/10.1002/chin.200505221
- Shen W.J., Qin M.J., Shu P., Zhang C.F. 2008. Two new C-glycosylflavones from the leaves of Iris lactea var. chinensis. – Chinese Chem. Lett. 19: 821–824. https://doi.org/10.1016/j.cclet.2008.04.031
- Meng Y., Qin M., Qi B., Xie G. 2017. Four new C-glycosylflavones from the leaves of Iris lactea Pall. var. chinensis (Fisch.) Koidz. – Phytochem. Lett. 22: 33–38. https://doi.org/10.1016/j.phytol.2017.08.011
- Niu Y.F., Shao Y., Zhao X.H., Wen H.X., Tao Y.D. 2008. [RP-hPLC determination of flavonoids in several flowers]. – Zhongguo Zhong Yao Za Zhi. 33(18): 2102–4. https://pubmed.ncbi.nlm.nih.gov/19160795/ (In Chinese)
- Jacobs M.L., Burlage H.M. 1958. Index of plants of North Carolina with reputed medicinal uses. Austin. 322 p.
- Kimura K., Kimura T. 1970. Medicinal Plants of Japan in Colour. Osaka. 139 p. (In Japanese)
- Shigemitsu O. 1938. [Medicinal Plant Raw Material]. Tokyo. (In Japanese)
- Uphof J.C.T. 1968. Dictionary of Economic Plants. Wurzburg. 591 p.
- Wang S.X., Liu M.F., Yuan L., Zhang W.L., Li D.H. 1986. Effects of irisquinone on cyclic nucleotides in plasma, cancer and other tissues of mice bearing U14 tumor. – Chin. J. Clin. Oncol. 13: 241–243.
- Li W.M., Wang S.H., Kuang P., Qu B.X., Song H.L., Zhu L.X. 1987. Radiosensitizing effect of an active principle Iq7611 from the seed of Iris lactea var. chinensis. – Tumor. 7: 97–99.
- Tang W., Hemm I., Bertram B. 2003. Recent Development of Antitumor Agents from Chinese Herbal Medicines; Part I. Low Molecular Compounds. – Planta Medica. 69(2): 97–108. https://doi.org/10.1055/s-2003-37718
- Aini H., Ochi H., Iwata M., Okawa A., Koga D., Okazaki M., Sano A., Asou Y. 2012. Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model. – PLoS One 7(5): e37728. https://doi.org/10.1371/journal.pone.0037728
- The Editorial Committee of Chinese Materia Medica, State Administration of Traditional Chinese Medicine. 1999. – Chinese Materia Medica. 22: 271–275.
- Cui Y.M., Wang H., Liu Q.R., Han M., Lu Y., Zhao C.Q. 2011. Flavans from Iris tenuifolia and their effects on β-amyloid aggregation and neural stem cells proliferation in vitro. – Bioorg. Med. Chem. Lett. 21(15): 4400–4403. https://doi.org/10.1016/j.bmcl.2011.06.039
- Otgon O., Nadmid S., Paetz C., Dahse H.M., Voigt K., Bartram S., Boland W., Dagvadorj E. 2021. Chromane Derivatives from Underground Parts of Iris tenuifolia and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation. – Molecules. 26(21): 6705. https://doi.org/10.3390/molecules26216705
- Ligaa U., Davaasuren B., Ninjil N. 2005. Medicinal Plants of Mongolia Used in Western and Eastern Medicine. Ulaanbaatar. 134 p. https://apps.who.int/iris/rest/bitstreams/920761/retrieve
- Jalsrai A., Numakawa T., Ooshima Y., Adachi N., Kunugi H. 2014. Phosphatase-Mediated Intracellular Signaling Contributes to Neuroprotection by Flavonoids of Iris tenuifolia. – Am. J. Chinese Med. 42(01): 119–130. https://doi.org/10.1142/S0192415X14500086
- Jalsrai A., Reinhold A., Becker A. 2017. Ethanol Iris tenuifolia extract reduces brain damage in a mouse model of cerebral ischaemia. – Phytother. Res. 32(2): 333–339. https://doi.org/10.1002/ptr.5981
- Pankova P.A. 1949. [Herbaceous plants containing vitamin C]. – In: [Plant raw materials. Proceedings of the Botanical Institute of the Academy of Sciences of the USSR]. 5(2): 292–478. (In Russian)
- Gubanov I.A., Krylova I.L., Tikhonova V.L. 1976. [Wild useful plants of the USSR]. Moscow. 360 p. (In Russian)
- Wang Y.Q., Tan J.J., Tan C.H., Jiang S.H., Zhu D.Y. 2003. Halophilols A and B, two new stilbenes from Iris halophila. – Planta Med. 69(8): 779–81. PMID: https://doi.org/10.1055/s-2003-4279214531035
- Kim J.-B., Kim K.-H., Hwang S.-K., Kim Y.-H., Cho K.-J., Hwang Y.-S., Park R.-D., Kim J.-B. 2001. The Composition of Useful Medium Chain Fatty Acids in Eight Plant Species. – J. Appl. Biol. Chem. 44(1): 20–23.
- Khare C. 2007 Indian Medicinal Plants. New York. https://doi.org/10.1007/978-0-387-70638-2_809
- Bhan M.K., George V., Kapoor R., Rishi A.K. 1976. Chemical investigation of local plants: Part I. – Indian J. Chem., Section B: Organic Chemistry Including Medicinal Chemistry. 14(6): 475–476.
- Iwashina T., Kamenosono K., Yabuya T. 1996a. Isolation and identification of flavonoid and related compounds as co-pigments from the flowers of Iris ensata. – J. Jap. Bot. 71: 281–287.
- Hayashi K. 1940a. Isolation of Ensatin, an Acylated Anthocyanin from the Flowers of Japanese Iris. – Proceedings of the Imperial Academy. 16(9): 478–481. https://doi.org/10.2183/pjab1912.16.478
- Hayashi K. 1940b. On the Anthocyan in the Flowers of Japanese Iris. (Preliminary Note.). – Shokubutsugaku Zasshi. 54(637): 23–28. https://doi.org/10.15281/jplantres1887.54.23
- Hayashi K. 1941. Studien über Anthocyane, VI. Über Ensatin, ein neues Anthocyanin der Blüten von Japanischen Schwertlilien. – Acta Phytochim. 12: 65–82.
- Hayashi K., Ootani S., Sato K., Tuyama S., Ishikura N. 1978. Chemotaxonomical studies on Japanese irises in relation to the flavonoids in flowers. – Res. Inst. Evolut. Biol. Sci. Rep. 1: 1–16. (In Japanese with English summary)
- Ishikura N., Yamamoto E. 1978. Anthocyanins in the flowers of Japanese garden iris belonging to “Higo” line. – Kumamoto J. Sci.: Biol. 14: 9–15.
- Karrer W. 1958. Konstitution und Vorkommen der organischen Pflanzenstoffe (exclusive Alkaloids). Basel-Stuttgart. 1207 s. (In German)https://doi.org/10.1007/978-3-0348-6808-2
- Yabuya T. 1987. High-performance liquid chromatographic analysis of anthocyanins in induced amphidiploids of Iris laevigata Fisch. × I. ensata Thunb. – Euphytica. 36(2): 381–387. https://doi.org/10.1007/BF00041481
- Yabuya T., Nakamura M., Yamasaki A. 1994. P-coumaroyl glycosides of cyanidin and peonidin in the flowers of Japanese garden iris, Iris ensata Thunb. – Euphytica. 74: 47–50. https://doi.org/10.1007/BF00033766
- Yabuya T., Imayama T., Shimomura T., Urushihara R., Yamaguchi M. 2001. New types of major anthocyanins detected in Japanese garden iris and its wild forms. – Euphytica. 118: 253–256. https://doi.org/10.1023/A:1017562518106
- Imayama T., Yabuya T. 2003. Characterization of Anthocyanins in Flowers of Japanese Garden Iris, Iris ensata Thunb. – Cytologia. 68(2): 205–210. https://doi.org/10.1508/cytologia.68.205
- Yabuya T. 1991. High-performance liquid chromatographic analysis of anthocyanins in Japanese garden iris and its wild forms. – Euphytica. 52(3): 215–219. https://doi.org/10.1007/BF00029398
- Kitahara K., Murai Y., Bang S.W., Kitajima J., Iwashina T., Kaneko Y. 2014. Anthocyanins from the Flowers of Nagai Line of Japanese Garden Iris (Iris ensata). – Nat. Prod. Commun. 9(2): 201–204. https://doi.org/10.1177/1934578X1400900216
- Iwashina T. 2003. Flavonoid function and activity to plants and other organisms. – Biol. Sci. Space. 17(1): 24–44. https://doi.org/10.2187/bss.17.24
- Boltenkov E.V., Rybin V.G., Zarembo E.V. 2005. Flavones from Callus Tissue of Iris ensata. – Chem. Nat. Compd. 41(5): 539–541. https://doi.org/10.1007/s10600-005-0200-1
- Vereshchagin V.I. 1959. [Useful plants of Western Siberia]. Moscow; Leningrad. 348 p. (In Russian)
- Pozdneev A.M. 1908. [Textbook of Tibetan medicine]. Vol. 1. Saint Petersburg. 425 p. (In Russian)
- Eom T., Kim J., Lee S., Jeong J. 2013. A herbalogical study on the plants of Iridaceae in Korea. – Korean J. Herbology. 28: 85–93. https://doi.org/10.6116/kjh.2013.28.3.85
- Ghobadi Pour M., Mirazi N., Seif A. 2019. Treatment of liver and spleen illnesses by herbs: Recommendations of Avicenna’s heritage “Canon of Medicine”. – Avicenna J. Phytomed. 9: 101–116.
- Kumar S., Pandey S. 2015. An ethnobotanical study of local plants and their medicinal importance in Tons river area, Dehradun, Uttarakhand. – Indian J. Trop. Biodiv. 23(2): 227–231. https://tfri.icfre.gov.in/IJTB-Journal/IJTB%2023(2)%202015/abstract/IJTB-23(2)%202015-(227-231).pdf
- Singh K.N., Lal B. 2008. Ethnomedicines used against four common ailments by the tribal communities of Lahaul-Spiti in western Himalaya. – J. Ethnopharmacol. 115(1): 147–159. https://doi.org/10.1016/j.jep.2007.09.017
- Singh K.N. 2012. Traditional knowledge on ethnobotanical uses of plant biodiversity: a detailed study from the Indian western Himalaya. – Biodiv. Res. Conserv. 28(1): 63–77. https://doi.org/10.2478/v10119-012-0028-z
- Zaman S., Farrukh H., Muhammad I. 2014. Traditional knowledge on plant resources of Ashezai and Salarzai Valleys, District Buner, Pakistan. – Afr. J. Plant Sci. 8(1): 42–53. https://doi.org/10.5897/AJPS12.067
- Shuaib M., Hussain F., Rauf A., Jan F., Romman M., Parvez R., Zeb A., Ali S., Abidullah S., Bahadur S., Shah A.A., Azam N., Dilbar S., Begum K., Khan H., Sajjad S., Muhammad I., Shah N.A. 2021. Traditional knowledge about medicinal plant in the remote areas of Wari Tehsil, Dir Upper, Pakistan. – Braz. J. Biol. 83: e246803. https://doi.org/10.1590/1519-6984.246803
- Kim E.T., Hwang H.S., Lee S.M., Lee S.J., Lee I.D., Lee S.K., Oh da S., Lim J.H., Yoon H.B., Jeong H.Y., Im S.K., Lee S.S. 2016. Effects of Medicinal Herb Extracts on In vitro Ruminal Methanogenesis, Microbe Diversity and Fermentation System. – Asian-Australas. J. Anim. Sci. 29(9): 1280–1286. https://doi.org/10.5713/ajas.16.0053
- Suresh D.K., Ahemad W., Khalid M.S., Aasim S.M. 2010. Anti-hyperglycemic Activity of Iris ensata Thunb. Root Extracts in Normal, Glucose Fed and Streptozotocin Induced Diabetic Rats. – Adv. Pharmacol. Toxicol. 11(3): 93–101. https://www.proquest.com/docview/837356853
- Saxena B.P., Srivastava J.B. 1972. Studies on plant extracts with juvenile hormone activity. Effects of Iris ensata Thamb. (Iridaceae) on Dysdercus koenigii F. (Pyrrochoridae). – Experientia. 28(1): 112–113. https://doi.org/10.1007/BF01928298
- Spangler J.T., Sample D.J., Fox L.J., Albano J.P., White S.A. 2019. Assessing nitrogen and phosphorus removal potential of five plant species in floating treatment wetlands receiving simulated nursery runoff. – Environ. Sci. Pollut. Res. 26: 5751–5768. https://doi.org/10.1007/s11356-018-3964-0
- Richardson P.M. 1983. The taxonomic significance of C-glycosylxantones in flowering plants. – Biochem. Syst. Ecol. 11(4): 371–375. https://doi.org/10.1016/0305-1978(83)90039-X
- Iwashina T., Ootani S. 1996b. Flavonoids in the flowers of Iris laevigata (Iridaceae). – Sci. Rep Res Inst Evolut Biol. 8: 41–48.
- Iwashina T., Ootani S. 1998. Flavonoids of the genus Iris: Structures, distribution and function (review). – Ann. Tsukuba Bot Gard. 17: 147–183. https://www.kahaku.go.jp/research/publication/tsukuba/download/17/ATBG17_147.pdf
- Marner F.-J., Littek A., Arold R., Seferiadis K., Jaenicke L. 1990. Isolation and structure determination of new spiro-bicyclic triterpenoids from Iris pseudacorus. – Liebigs Ann. Chem. 6: 563–567. https://doi.org/10.1002/jlac.1990199001105
- Jaenicke L., Marner F.-J. 1986. The Irones and Their Precursors. Fortschritte Der Chemie Organischer Naturstoffe. – In: Progress in the Chemistry of Organic Natural Products. 1–25. https://doi.org/10.1007/978-3-7091-8888-0_1
- Zatylnikova O.A., Kovalev V.N., Kovalev S.V. 2013. Composition of Iris pseudacorus (Iridaceae) Essential Oil. – Rastitelnye resursy. 49(2): 233–240. https://elibrary.ru/item.asp?id=18925981 (In Russian)
- Mikhailenko O.A. 2014. [Comparative analysis of the component composition of the essential oil of fresh and dried rhizomes of yellow iris (Iris pseudacorus)]. – In: [New advances in chemistry and chemical technology of plant raw materials: Materials of the VI All-Russian Conference]. Barnaul. P. 210–212. https://www.elibrary.ru/item.asp?id=22401392&pff=1 (In Russian)
- Henshaw G.G., Coult D.A., Boulter D. 1962. Organic acids of the rhizome of Iris pseudacorus. – Nature. 194: 579–580. https://doi.org/10.1038/194579b0
- Boulter D., Coult D.A., Henshaw G.G. 1963. Some Effects of Gas Concentrations on Metabolism of the Rhizome of Iris pseudacorus L. – Physiol. Plant. 16(3): 541–548. https://doi.org/10.1111/j.1399-3054.1963.tb08331.x
- Tarbeeva D.V., Fedoreev S.A., Veselova M.V., Kalinovskii A.I., Gorovoi P.G., Vishchuk O.S., Zadorozhnyi P.A. 2015. Polyphenolic Metabolites from Iris pseudacorus Roots. – Chem. Nat. Compd. 51(3): 451–455. https://doi.org/10.1007/s10600-015-1313-9
- Mykhailenko O., Gudžinskas Z., Kovalyov V., Desenko V., Ivanauskas L., Bezruk I., Georgiyants V. 2020. Effect of ecological factors on the accumulation of phenolic compounds in Iris species from Latvia, Lithuania and Ukraine. – Phytochem. Anal. 31(5): 545–563. https://doi.org/10.1002/pca.2918
- Mykchailenko O.O., Kovalyov M.V. 2016. Phenolic compounds of the genus Iris plants (Iridaceae). – Čes. slov. Farm. 65(2): 70–77. https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2016-2-12/fenolicke-slouceniny-rostlin-rodu-iris-iridaceae-58506
- Michalak A., Krauze-Baranowska M., Migas P., Kawiak A., Kokotkiewicz A., Królicka A. 2021. Iris pseudacorus as an easily accessible source of antibacterial and cytotoxic compounds. – J. Pharm. Biomed. 195: 113863. https://doi.org/10.1016/j.jpba.2020.113863
- Ali A.A., El-Emary N.A., Darwish F.M. 1993. Studies on the constituents of two Iris species. – Bull. Pharm. Sci., Assiut Univ. 16(2): 159–162. https://doi.org/10.21608/bfsa.1993.70202
- Isaev D.I., Kerimov U.B., Kovalyov S.V., Zatylnikova O.O. 2010. [Isoflavones from rhizomes of Iris imbricata Lindl. and Iris pseudacorus L.] – Pharmacom. 1. 38–42. http://sphu.org/wp-content/uploads/2017/01/Farmacom_1_2010.pdf (In Russian)
- Isaev D.I., Kerimov U.B., Kovalyov S.V., Zatylnikova O.O. 2009. Xanthones from rhizomes of Iris imbricata Lindl. and Iris pseudacorus L. – Pharmacom. 4: 24–28. http://sphu.org/wp-content/uploads/2017/08/Farmacom_4_2009.pdf (In Russian)
- Senatore F., Randazzo A., Rigano D. 2003. Pyrrolidin-2-one derivatives from Iris pseudacorus (Iridaceae). – Biochem. Syst. Ecol. 31(6): 657–659. https://doi.org/10.1016/S0305-1978(02)00228-4
- Cardenas M.L., Kickuth R. 1978. Secondary metabolites from macrophytes and their ecochemical function. Part 3. 3–(3-carboxyphenyl)alanine as constituent and excretion product of Iris pseudacorus. – Angew. Bot. 52: 203–214.
- Sutherland W.J. 1990. Iris pseudacorus L. – J. Ecol. 78(3): 833. https://doi.org/10.2307/2260902
- Zatylnicova O.A., Kovalev S.V. 2009. Study of amino acids and mineral composition of the underground organs of Iris pseudacorus L. – Pharmacom. 1: 45–47. http://sphu.org/wp-content/uploads/2017/08/Farmacom_1_2009.pdf (In Ukrainian)
- Tarbeeva D.V. 2016. [Polyphenolic metabolites of Iris pseudacorus L. and its cell culture: Abstr. … Diss. Cand. (Chemistry) Sci.]. Vladivostok. 24 p. (In Russian)
- Kovalev V.N., Mikhailenko O.A., Kovalev S.V. 2013b. Coumarins of yellow iris Iris pseudacorus L. – Khimija rastitel’nogo syr’ja. 3: 201–205. (In Russian)https://doi.org/10.14258/jcprm.1303201
- Hanawa F., Tahara S., Mizutani J. 1991a. Isoflavonoids produced by Iris pseudacorus leaves treated with cupric chloride. – Phytochemistry. 30(1): 157–163. https://doi.org/10.1016/0031-9422(91)84117-B
- Hanawa F., Tahara S., Mizutani J. 1991b. Flavonoids produced by Iris pseudacorus leaves treated with cupric chloride. – Phytochemistry. 30(7): 2197–2198. https://doi.org/10.1016/0031-9422(91)83613-P
- Sary H.G., Ayoub N.A., Singab A.B., Ahmed A.H., Al-Azizi M.M. 2004. Chemical constituents and molluscicidal activity of Iris pseudacorus L. cultivated in Egypt. – Bull. Pharm. Sci., Assiut University. 27(1): 161–9. https://doi.org/10.21608/bfsa.2004.65438
- Bate-Smith E.C., Harborne J.B. 1963. Mangiferin and other glycophenolics in Iris species. – Nature. Vol. 198. № 4887. P. 1307–1308. https://doi.org/10.1038/1981307a0
- Zatylnikova O.O., Kovalyov S.V., Osolodchenko T.P., Akhmedov E.Yu. 2012. Investigation of the lipophilic fraction from leaves of yellow iris. – Вісник фармації. 3(71): 57–59. https://dspace.nuph.edu.ua/bitstream/123456789/2055/1/VF2012_3.pdf (In Ukrainian with English and Russian summary)
- Tarbeeva D.V., Fedoreev S.A., Veselova M.V., Kalinovskii A.I., Gorovoi P.G. 2014. Polyphenolic metabolites from Iris pseudacorus. – Chem. Nat. Compd. 50(2): 363–365. https://doi.org/10.1007/s10600-014-0955-3
- Stanley R.G., Linskens H.F. 1974. Pollen: biology, biochemistry and management. 310 p. https://doi.org/10.1007/978-3-642-65905-8
- O’Connor W.F., Drumm P.J. 1941. Pigments of Iris pseudacorus. – Nature. 147(3715): 58–59. https://doi.org/10.1038/147058b0
- Drumm P.J., O’Connor W.F. 1945. The pigments of the yellow iris (Iris pseudacorus). – Biochem. 39(2): 211–212. https://doi.org/10.1042/bj0390211
- Steinmetz E.F. 1957. Codex vegetabilis. Amsterdam. 136 p.
- Villeret S. 1974. Sur l'évolution des acides gras majeurs des fleurs d’Iris pseudacorus L. – C.R. Acad. Sci. (Paris). 278: 1213–1216. (In French)
- Seki K., Kaneko R. 1975. Structure of irisquinone: A new quinone from Iris pseudacorus L. (Iridaceae). – Chem. Ind. H. 8: 349–350.
- Kato T., Seki K., Kaneko R. 1986. Insoluble monolayers of irisquinone and its related substances at the air/water interface. – J. Colloid Interface Sci. 109(1): 77–89. https://doi.org/10.1016/0021-9797(86)90283-3
- Marner F.-J., Horper W. 1992a. Phenols and Quinones from Seeds of Different Iris Species. – Helvetica Chimica Acta. 75(5): 1557–1562. https://doi.org/10.1002/hlca.19920750509
- Zhou J., Xie G., Yan X. 2011. Encyclopedia of traditional Chinese medicines molecular structures, pharmacological activities, natural sources and applications. Vol. 3. Isolated Compounds H–M. 669 p. https://doi.org/10.1007/978-3-642-16747-8
- Maciejewska-Potapczyk W., Saniewski M., Pełczyńska M. 1974. Sugars in Iris pseudoacorus L. seeds. – Acta Soc. Bot. Pol. 43: 195–202. https://doi.org/10.5586/asbp.1974.018
- Lotti G., Averna V. 1969. [Seed lipids of water plants. – The Italian review of fatty substances. Vol. XLVI. 668–72]. Fisheries Research Board of Canada. Translation Series № 1500. 1970. https://waves-vagues.dfo-mpo.gc.ca/library-bibliotheque/139713.pdf (Transl. form Italian)
- Tarbeeva D.V., Fedoreyev S.A., Veselova M.V., Kalinovskiy A.I., Seletskaya L.D., Mazurok T.I., Bulgakov V.P. 2013 Polyphenolic compounds from callus cultures of Iris pseudacorus. – Nat. Prod. Commun. 8(10): 1419–1420. https://doi.org/10.1177/1934578X1300801020
- Freerksen E., Bönicke R. 1951. Über antibakterielle Prinzipien in höheren Pflanzen I. – Zeitschrift Für Hygiene Und Infektionskrankheiten. 132(5): 417–449. https://doi.org/10.1007/BF02149068
- Nickell L.G. 1959. Antimicrobial activity of vascular plants. – Economic Botany. 13(4): 281–318. https://doi.org/10.1007/BF02885664
- Ramtin M., Pahlaviani M.R.M.K, Massiha A., Issazadeh K., Heidari S. 2013. Comparative evaluation of the antibacterial activities of essential oils of Iris pseudacorus and Urtica dioica native north of Iran. – J. Pure Appl .Microbiol. 7(2): 1065–1070. https://microbiologyjournal.org/comparative-evaluation-of-the-antibacterial-activities-of-essential-oils-of-iris-pseudacorus-and-urtica-dioica-native-north-of-iran/
- Zatylnikova O.A., Osolodchenko T.P., Kovalev V.N. 2010. Antimicrobial activity of extracts of Iris pseudacorus L. – Annals of Mechnikov Institute. 4: 43–47. http://nbuv.gov.ua/UJRN/ami_2010_4_7 (In Ukrainian)
- Okba M.M., Abdel Baki P.M., Abu-Elghait M., Shehabeldine A.M., El-Sherei M.M., Khaleel A.E., Salem M.A. 2022. UPLC-ESI-MS/MS profiling of the underground parts of common Iris species in relation to their anti-virulence activities against Staphylococcus aureus. – J. Ethnopharmacol. 282: 114658. https://doi.org/10.1016/j.jep.2021.114658
- [Wild medicinal plants]. 1965. Minsk. 361 p. (In Russian)
- Dimkov P. 1978. [Bulgarian folk medicine]: In 3 volumes. Sofia. Vol. 2. 823 p.; 1979. Vol. 3. 678 p. (In Bulgarian)
- Rollov A.H. 1908. [Wild plants of the Caucasus, their distribution, properties and application]. Tiflis. 599 p.
- Grintsevich O.M. 1933. [Medicinal plants of the Western region]. – [Materials for the study of the natural productive forces of the western regions]. Smolensk. Iss. 3. P. 19–106. (In Russian)
- Volkind I.V., Gurevich I.Ya., Uryupov O.Yu. 1976. [Drug handbook for doctors and pharmacists]. Leningrad. 647 p. (In Russian)
- Yakovlev G.P., Blinova K.F. 1990. [Botanical-pharmacognostic dictionary]. Moscow. 192 p. (In Russian)
- Frohne D., Pfänder H.J. 1983. Giftpflanzen. 2nd ed. Stuttgart. 137 p.
- Roth L., Daunderer M., Kormann K. 1984. Giftpflanzen – Pflanzengifte. München. 1032 p.
- Crișan I., Cantor M. 2017. New perspectives on medicinal properties and uses of Iris sp. – Hop Med. Plants. 24: 24–36.
- Khokhlova N.A., Derkach N.V., Zatylnikova O.A., Kovalev V.N., Volkovoy V.A. 2012. Pharmacological study of I. pseudocorus L. – Ukrainian biopharmaceutical journal. 1–2: 42–45. http://nbuv.gov.ua/UJRN/ubfj_2012_1-2_12 (in Ukrainian)
- Grossgeim A.A. 1952. [Plant wealth of the Caucasus]. 2nd ed. Moscow. 632 p. (In Russian)
- Klobukova-Alisova E.N. 1958. [Wild-growing useful and harmful plants of Bashkiria]. In 2 volumes. Moscow; Leningrad. Vol. 1. 218 p.; Vol. 2. 247 p. (In Russian)
- Geideman T.C., Ivanova B.I., Lyalikov S.I. Nikolaev L.P., Pozharisskaya L.P., Kholodenko B.G., Shkolnikova T.A., Shutov D.A. 1962. [Useful wild plants of Moldova]. Kishinev. 416 p. (In Russian)
- Bgazhba M.T. 1964. Plant resources of Abkhazia and their use. Sukhumi. 579 p. (In Russian)
- Ahmed A.H., El Hamshary E.M. 2005. Larvicidal, miracidiacidal and cercaricidal activities of the Egyptian plant Iris pseudacorus. – J. Egypt. Soc. Parasitol. 35(1): 41–48.
- Keizer-Vlek H.E., Verdonschot P.F.M., Verdonschot R.C.M., Dekkers D. 2014. The contribution of plant uptake to nutrient removal by floating treatment wetlands. – Ecol. Eng. 73: 684–690. https://doi.org/10.1016/j.ecoleng.2014.09.081
- Mizuno T., Okuyama Y., Iwashina T. 2018. Flavonoids from Iris sanguinea var. tobataensis and chemotaxonomic and molecular phylogenetic comparisons with Iris sanguinea var. sanguinea. – Bull. Natl. Mus. Nat. Sci. Ser. B. 44(3): 135–145. https://www.kahaku.go.jp/research/researcher/papers/74783.pdf
- Hirose R., Kazuta Y., Koga D., Ide A., Yagishita K. 1981. On the Structure of C-Glycosyl Flavones, Flavoayamenin and Luteoayamenin, in Petals of Iris nertshinskia Loddiges form albiflora Honda. – Agric. Biol. Chem. 45(3): 551–555. https://doi.org/10.1080/00021369.1981.10864564
- Kawase A. 1968. Studies on the Flavonoid of Iridaceae. – Agricultural and Biological Chemistry. 32(8): 1028–1032. https://doi.org/10.1080/00021369.1968.10859167
- Morita N. 1976. Relation of the classification and the component on plant – Application to the chemotaxonomy in connection with flavonoid. – Kagaku kyoiku. 22: 475–483 (In Japanese).
- Marner F.-J., Longerich I. 1992b. Isolation and Structure Determination of new Iridals from Iris sibirica and Iris versicolor. – Liebigs Ann. Chem. (3): 269–272. https://doi.org/10.1002/jlac.199219920146
- Marner F.-J., Simic K., Scholz B., Küster B. 1995. Isolation and Structure Determination of a New Iridal from Iris sibirica. – J. Nat. Prod. 58(2): 299–301. https://doi.org/10.1021/np50116a026
- Bjoroy O., Rayyan S., Fossen T., Kalberg K., Andersen O.M. 2009. C-glycosylanthocyanidins synthesized from C-glycosylflavones. – Phytochemistry. 70(2): 278–287. https://doi.org/10.1016/j.phytochem.2008.12.012
- Karpitskiy D.A., Bessonova E.A., Kartsova L.A., Tikhomirova L.I. 2022. Development of approach for flavonoid profiling of biotechnological raw materials Iris sibirica L. by HPLC with high-resolution tandem mass spectrometry. – Phytochem. Anal. 33(6): 869–878. https://doi.org/10.1002/pca.3135
- Bate-Smith E.C., Swain T. 1965. Recent developments in the chemotaxonomy of flavonoid compounds. – Lloydia. 28: 313–331.
- Andrews P., Hough L., Jones J.K.N. 1953. 238. Mannose-containing polysaccharides. Part III. The polysaccharides in the seeds of Iris ochroleuca and I. sibirica. – J. Chem. Soc. (Resumed). 1186–1192. https://doi.org/10.1039/jr9530001186
- Kurentsova G.E. 1941. [Medicinal plants of the Soviet Far East]. – [Proceedings of the Far Eastern mountain-taiga station Voroshilov-Ussuriyskiy]. 4: 131–226. (In Russian)
- Skalozubov N.L. 1913. [Botanical Dictionary: Popular names of plants in the Tobolsk Governorate]. – Annuaire du muse de Tobolsk. Livr. XXI. P. 1–87. https://www.prlib.ru/item/331768 (In Russian)
- Krylov P. 1876. [On the folk medicinal plants used in the Perm Governorate]. – [Proceedings of the Imperial Kazan University Society of Naturalists]. 5(2). 131 p. https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000492012 (In Russian)
- Grossgeim A.A. 1940. Fam. Iridaceae Lindl. – In: [Flora of the Caucasus]. Baku. Vol. 2. P. 200–227. (In Russian)
- Kaššák P., Kuli M. 2014. Dyeing potential of the Iris sibirica flowers. – Eur. Sci. J. Special Edition 2: 372–380.
- Silva J.D., Nascimento M.G., Castro K.N., Andrade I.M. 2015. Ethnobotanical survey of medicinal plants used by the community of Sobradinho, Lus Correia, Piau, Brazil. – J. Med. Plant Res. 9: 872–883. https://doi.org/10.5897/JMPR2015.5881
- Kovalev V.M., Mykhailenko O.O., Krechun A.V., Osolodchenko T.P. 2017. Antimicrobial activity of extracts of Iris hungarica and Iris sibirica. – Annals of Mechnikov Institute. 2: 57–64. https://doi.org/10.5281/zenodo.803878
- Hayashi K., Ootani S., Iwashina T. 1989. Comparative analysis of the flavonoid and related compounds occurring in three varieties of Iris setosa in the flora of Japan. – Res. Inst. Evolut. Biol. Sci. Rep. 6: 30–60. (In Japanese with English summary)
- Iwashina T., Ootani S. 1995. Polyphenols in Iris setosa var. canadensis and their chemotaxonomic comparisons with three Japanese varieties. – Ann. Tsukuba Bot. Gard. 14: 35–41. https://www.kahaku.go.jp/research/publication/tsukuba/download/14/ATBG14_35.pdf
- Ueno N., Takemura E., Hayashi K. 1969. Additional Data for the Paperchromatographic Survey of Anthocyanins in the Flora of Japan (IV). – Shokubutsugaku Zasshi. 82(970): 155–161. https://doi.org/10.15281/jplantres1887.82.155
- Makarov A.A. 1970. [Medicinal plants of Yakutia]. Yakutsk. 179 p. (In Russian)
- Arifkhodzhaev A.D., Ismailov Z.F. 1980. [Iris polysaccharides]. – Khimija Prirodnykh Soyedineniy. 6: 822–823. (In Russian)
- Zakharov A.M., Boriaev K.I. 1968. [Search for plants containing biologically active compounds in the flora of the Middle Asia and Kazakhstan]. – Rastitelnye resursy. 4(2): 243–257. (In Russian)
- Minaeva V.G., Kiseleva A.A., Volkhonskaya T.A. 1973. [Some results of the survey of plants in the Krasnoyarsk Territory for the content of flavonoid substances]. – [Promising useful plants of Siberian flora]. Novosibirsk. P. 170–178. (In Russian)
- Makarenko A.A. 1897. [Materials on folk medicine of the Uzhur volost, Achinsk district, Yenisei Governorate with an appendix of a collection of folk medicines from the same volost]. Saint Petersburg. 438 p. https://elib.rgo.ru/handle/123456789/229308 (In Russian)
- Dzhavanshir E.I., Kerimov Y.B. 2005. Study of fatty acids in lipids from four Iris varieties. – Azerb. Eczacil. J. 5(2): 26–30; Chem. Abstrs. 2007. 146: 247424.
- Bondarenko A.S., Schweiger M.O., Mandrik T.P., Poddubnaya N.M., Skorobogatko T.I., Mozgovaya L.F., Kolesova E.A. 1967. [Antibacterial activity of plants from the botanical gardens of Ashgabat and Dushanbe]. – [Phytoncides, their biological role and significance for medicine and the national economy]. Kyiv. P. 102–106. (In Russian)
- Mykhailenko O., Kovalyov V., Kovalyov S., Krechun A. 2017. Isoflavonoids from the rhizomes of Iris hungarica and antibacterial activity of the dry rhizomes extract. – Ars. Pharm. 58: 39–45. https://doi.org/10.30827/ars.v58i1.5919
- Mykhailenko O., Gudžinskas Z., Romanova S., Orlova T., Kozyra S., Harna S., Volochai V. 2021. The Comparative Analysis of Carboxylic Acid Composition of Four Iris Species from Ukraine. – Chem. Biodivers. 18(3): e2000969. https://doi.org/10.1002/cbdv.202000969
- Rybak V., Kerimova G., Korol V. 2021. Investigation of the anabolic activity of dry extracts of Iris hungarica leaves and rhizomes on the model of hydrocortisone-induced protein catabolism. – Čes. slov. Farm. 70(2): 59–65. https://doi.org/10.5817/CSF2021-2-59
- Kostić A.Ž., Gašić U.M., Pešić M.B., Stanojević S.P., Barać M.B., Mačukanović-Jocić M.P., Tešić Ž.L. 2019. Phytochemical analysis and total antioxidant capacity of rhizome, above-ground vegetative parts and flower of three Iris species. – Chem. Biodivers. 16(3): e1800565. https://doi.org/10.1002/cbdv.201800565
- Yuan Y., Sun Y., Zhao Y., Liu C., Chen X., Li F., Bao J. 2019. Identification of Floral Scent Profiles in Bearded Irises. – Molecules. 24(9): 1773. https://doi.org/10.3390/molecules24091773
- Zhou J., Xie G., Yan X. 2011. Encyclopedia of traditional Chinese medicines molecular structures, pharmacological activities, natural sources and applications. Vol. 2. Isolated compounds D-G. 525 p. https://doi.org/10.1007/978-3-642-16738-6
- Singab A.N.B., Ayoub I.M., El-Shazly M., Korinek M., Wu T.-Y., Cheng Y.-B., Chang F.-R., Wu Y.-C. 2016. Shedding the light on Iridaceae: Ethnobotany, phytochemistry and biological activity. – Ind. Crops Prod. 92: 308–335. https://doi.org/10.1016/j.indcrop.2016.07.040
- Purevsuren Ts. 2004. Bioactive compounds from Iris potaninii Maxim. – A thesis submitted for the degree of Doctor of Philosophy in Biology. Ulaanbaatar: National University of Mongolia. 111 p.
- Medicinal Plants in Mongolia. 2013. Weltgesundheitsorganisation Regional Office for the Western Pacific. 235 p.
- Ageev V.E. 1989. [Medicinal plants of Adzharia]. Tbilisi. 61 p. (In Russian)
- Aseeva T.A., Tarmaeva Z.V., Logina O.K., Bukhasheeva T.K., Trifonova G.P., Andreeva L.B. 1987. [Resources of medicinal plants in Buryatia]. – [Plant resources of Transbaikalia and their use]. Ulan-Ude. pp. 41–61. (In Russian)
- Telyatiev V.V. 1985. [Useful plants of Central Siberia]. Irkutsk. 400 p. (In Russian)