Prospects for Infrared Luminescent Diagnostics of Superficially
- Авторлар: Shilov I.1, Rumyantseva V.1, Ivanov A.2,3, Alekseev Y.3, Gorshkova A.1, Ryabov M.3, Kovaleva A.4, Kovalev M.5
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Мекемелер:
- Kotelniov Institute of Radioengineering and Electronics, Fryazino Branch, Russian Academy of Science
- National Medical Research Center of Oncology
- Skobelin Scientific and Practical Center for Laser Medicine, Federal Medical-Biological Agency
- Pletnev City Clinical Hospital
- Sechenov First Moscow State Medical University
- Шығарылым: Том 68, № 4 (2023)
- Беттер: 399-406
- Бөлім: ПРИМЕНЕНИЕ РАДИОТЕХНИКИ И ЭЛЕКТРОНИКИ В БИОЛОГИИ И МЕДИЦИНЕ
- URL: https://journals.rcsi.science/0033-8494/article/view/138206
- DOI: https://doi.org/10.31857/S0033849423030130
- EDN: https://elibrary.ru/IDRXEU
- ID: 138206
Дәйексөз келтіру
Аннотация
In this paper, we developed a promising technique for luminescent infrared (IR) diagnostics of neoplasms of visually and endoscopically accessible localization (dermatology, gynecology, dentistry) using ytterbium complexes of porphyrins. Possible mechanisms of accumulation of a pharmaceutical composition based on the ytterbium complex of 2,4-di(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP) in tumor tissues were studied. Studies on the pharmacokinetics and biodistribution of this substance in various organs and neoplasms of laboratory animals showed a significant selectivity of the accumulation of nanoparticles with ytterbium ions in tumors as early as 24 h after intravenous administration. For the purposes of luminescent IR diagnostics, a highly sensitive laser-fiber fluorimeter operating in the spectral range of 900–1100 nm was developed. Preclinical tests of the developed method of fluorescent IR cancer diagnostics were carried out and its prospects were shown.
Авторлар туралы
I. Shilov
Kotelniov Institute of Radioengineering and Electronics, Fryazino Branch, Russian Academy of Science
Email: laserlab@ms.ire.rssi.ru
Moscow oblast, Fryazino, 141190 Russia
V. Rumyantseva
Kotelniov Institute of Radioengineering and Electronics, Fryazino Branch, Russian Academy of Science
Email: laserlab@ms.ire.rssi.ru
Moscow oblast, Fryazino, 141190 Russia
A. Ivanov
National Medical Research Center of Oncology; Skobelin Scientific and Practical Center for Laser Medicine, Federal Medical-Biological Agency
Email: laserlab@ms.ire.rssi.ru
Moscow, 115522 Russia; Moscow, 121165 Russia
Yu. Alekseev
Skobelin Scientific and Practical Center for Laser Medicine, Federal Medical-Biological Agency
Email: laserlab@ms.ire.rssi.ru
Moscow, 121165 Russia
A. Gorshkova
Kotelniov Institute of Radioengineering and Electronics, Fryazino Branch, Russian Academy of Science
Email: laserlab@ms.ire.rssi.ru
Moscow oblast, Fryazino, 141190 Russia
M. Ryabov
Skobelin Scientific and Practical Center for Laser Medicine, Federal Medical-Biological Agency
Email: laserlab@ms.ire.rssi.ru
Moscow, 121165 Russia
A. Kovaleva
Pletnev City Clinical Hospital
Email: laserlab@ms.ire.rssi.ru
Moscow, 105077 Russia
M. Kovalev
Sechenov First Moscow State Medical University
Хат алмасуға жауапты Автор.
Email: laserlab@ms.ire.rssi.ru
Moscow, 119435 Russia
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