Characteristics of δ-Aminolevulenic Acid Dehydratase of the Cold-Water Sponge  Halisarca dujardinii

O. I. Kravchuk; Кравчук О. И.; E. I. Shagimardanova; Шагимарданова Е. И.; V. S. Mikhailov; Михайлов В. С.; A. I. Zhurakovskaya; Жураковская А. И.; N. G. Gornostaev; Горностаев Н. Г.; K. I. Adameyko; Адамейко К. И.; R. H. Ziganshin; Зиганшин Р. Х.; K. V. Mikhailov; Михайлов К. В.; A. D. Finoshin; Финошин А. Д.; Yu. V. Lyupina; Люпина Ю. В.

doi:10.31857/S0026898423060113

Characteristics of δ-Aminolevulenic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii

Autores: Kravchuk O.¹, Shagimardanova E.², Mikhailov V.¹, Zhurakovskaya A.¹, Gornostaev N.¹, Adameyko K.¹, Ziganshin R.³, Mikhailov K.⁴^,5, Finoshin A.¹, Lyupina Y.¹
Afiliações:
1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences
2. Institute of Fundamental Medicine and Biology, Kazan Federal University
3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
4. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
5. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences
Edição: Volume 57, Nº 6 (2023)
Páginas: 1085-1097
Seção: РОЛЬ РЕДОКС-ЗАВИСИМЫХ БЕЛКОВ В РЕАЛИЗАЦИИ РЕДОКС-РЕГУЛЯЦИИ КЛЕТОК
URL: https://journals.rcsi.science/0026-8984/article/view/231957
DOI: https://doi.org/10.31857/S0026898423060113
EDN: https://elibrary.ru/QFTCTO
ID: 231957

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Resumo

Delta-aminolevulinic acid dehydratase (ALAD) is a key enzyme in the cytoplasmic pathway of heme biosynthesis. Here, a primary structure of the ALAD gene of the marine cold-water sponge Halisarca dujardinii, a multimeric structure of the ALAD/hemB protein, and the ALAD gene expression during the sponge annual reproductive cycle were analyzed. On the base of results obtained one can suppose that the sponge ALAD gene expression is regulated by the transcription factor GATA-1 and DNA methylation. Re-aggregation of the sponge cells was accompanied by a decrease in ALAD expression and a change in the cellular content of the active ALAD/hemB form. Further study of heme biosynthesis and the role of ALAD/hemB in morphogenesis of basal animals may provide new opportunities for correcting pathologies in higher animals.

Palavras-chave

heme biosynthesis, δ-aminolevulenic acid dehydratase, basal animals, plasticity

Bibliografia

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