Cytochrome bd as Antioxidant Redox Enzyme
- Autores: Borisov V.1, Nastasi M.2, Forte E.2
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Afiliações:
- Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University
- Department of Biochemical Sciences, Sapienza University of Rome
- Edição: Volume 57, Nº 6 (2023)
- Páginas: 1084-1084
- Seção: РОЛЬ РЕДОКС-ЗАВИСИМЫХ БЕЛКОВ В РЕАЛИЗАЦИИ РЕДОКС-РЕГУЛЯЦИИ КЛЕТОК
- URL: https://journals.rcsi.science/0026-8984/article/view/231956
- DOI: https://doi.org/10.31857/S0026898423060034
- EDN: https://elibrary.ru/QOYAOW
- ID: 231956
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Resumo
One of the main functions of enzyme complexes that constitute electron transport (respiratory) chains of organisms is to maintain cellular redox homeostasis by oxidizing reducing equivalents, NADH and quinol. Cytochrome bd is a unique terminal oxidase of the chains of many bacteria including pathogenic species. This redox enzyme couples the oxidation of ubiquinol or menaquinol by molecular oxygen to the generation of proton motive force, a universal energy currency. The latter is used by the organism to produce ATP, another cellular energy currency, via oxidative phosphorylation. Escherichia coli contains two bd–type oxidases, bd-I and bd-II, encoded by the cydAB and appCB operons, respectively. Surprisingly, both bd enzymes make a further contribution to molecular mechanisms of maintaining the appropriate redox balance in the bacterial cell by means of elimination of reactive oxygen species, such as hydrogen peroxide. This review summarizes recent data on the redox-modulated H2O2-scavenging activities of cytochromes bd-I and bd-II from E. coli. The possibility of such antioxidant properties in cytochromes bd from other bacteria is also discussed.
Sobre autores
V. Borisov
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University
Autor responsável pela correspondência
Email: bor@belozersky.msu.ru
Russia, 119991, Moscow
M. Nastasi
Department of Biochemical Sciences, Sapienza University of Rome
Email: bor@belozersky.msu.ru
Italy, I-00185, Rome
E. Forte
Department of Biochemical Sciences, Sapienza University of Rome
Email: bor@belozersky.msu.ru
Italy, I-00185, Rome