Транскрипционный фактор NRF2 в функционировании эндотелия
- Авторы: Кондратенко Н.Д.1,2, Зиновкина Л.А.3, Зиновкин Р.А.1,2
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Учреждения:
- Научно-исследовательский институт физико-химической биологии им. А.Н. Белозерского, Московский государственный университет им. М.В. Ломоносова
- Российский научно-исследовательский медицинский университет им. Н.И. Пирогова, Российский геронтологический научно-клинический центр
- Факультет биоинженерии и биоинформатики Московского государственного университета им. М.В. Ломоносова
- Выпуск: Том 57, № 6 (2023)
- Страницы: 1058-1076
- Раздел: РОЛЬ РЕДОКС-ЗАВИСИМЫХ БЕЛКОВ В РЕАЛИЗАЦИИ РЕДОКС-РЕГУЛЯЦИИ КЛЕТОК
- URL: https://journals.rcsi.science/0026-8984/article/view/231953
- DOI: https://doi.org/10.31857/S0026898423060101
- EDN: https://elibrary.ru/QXHFSB
- ID: 231953
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Аннотация
Транскрипционный фактор NRF2 – главный регулятор антиоксидантной защиты клетки, активируется под воздействием различных стимулов, таких как окислители и электрофилы, что индуцирует транскрипцию целого ряда генов, продукты которых участвуют в метаболизме ксенобиотиков и способствуют уменьшению окислительного стресса. NRF2 является одним из ключевых транскрипционных факторов, обеспечивающих функционирование клеток эндотелия – слоя клеток, выстилающих внутреннюю полость сосудов. Эндотелий выполняет множество гомеостатических функций: контролирует миграцию лейкоцитов во внутренние ткани, регулирует тромбообразование и сосудистый тонус, а также участвует в ангиогенезе. Нарушение функций эндотелия часто сопровождается воспалением и окислительным стрессом, что может приводить к клеточному старению, а также к гибели клеток путем апоптоза, некроза и ферроптоза. Эндотелиальная дисфункция вносит вклад в развитие таких распространенных сердечно-сосудистых заболеваний, как гипертензия и атеросклероз, а также сахарного диабета. Многие патофизиологические процессы в эндотелии, включая старческие изменения, сопряжены со снижением активности NRF2, что приводит к воспалительной активации и снижению активности систем антиоксидантной защиты клетки. Активация сигнального пути NRF2, как правило, способствует разрешению воспаления и устранению окислительного стресса. В данном обзоре рассмотрено значение NRF2 в осуществлении основных функций эндотелия в норме и патологии, а также преимущества и недостатки активации NRF2 как способа профилактики и лечения сердечно-сосудистых заболеваний.
Об авторах
Н. Д. Кондратенко
Научно-исследовательский институт физико-химической биологии им. А.Н. Белозерского,Московский государственный университет им. М.В. Ломоносова; Российский научно-исследовательский медицинский университет им. Н.И. Пирогова,
Российский геронтологический научно-клинический центр
Email: roman.zinovkin@gmail.com
Россия, 119991, Москва; Россия, 129226, Москва
Л. А. Зиновкина
Факультет биоинженерии и биоинформатики Московского государственного университета им. М.В. Ломоносова
Email: roman.zinovkin@gmail.com
Россия, 119991, Москва
Р. А. Зиновкин
Научно-исследовательский институт физико-химической биологии им. А.Н. Белозерского,Московский государственный университет им. М.В. Ломоносова; Российский научно-исследовательский медицинский университет им. Н.И. Пирогова,
Российский геронтологический научно-клинический центр
Автор, ответственный за переписку.
Email: roman.zinovkin@gmail.com
Россия, 119991, Москва; Россия, 129226, Москва
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