Enviar artigo por via de e-mail Association of Polymorphic Genome Variants in the 2q32.1 Locus with the Development of Vasovagal Syncope
- Autores: Matveeva N.1,2, Titov B.1,2, Bazyleva E.1, Kuchinskaya Е.1, Kozin M.1,2, Favorov A.3, Pevzner A.1, Favorova O.1,2
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Afiliações:
- National Medical Research Center for Cardiology named after academician E.I. Chazov, Ministry of Health of the Russian Federation
- Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Johns Hopkins School of Medicine
- Edição: Volume 57, Nº 5 (2023)
- Páginas: 827-832
- Seção: ГЕНОМИКА. ТРАНСКРИПТОМИКА
- URL: https://journals.rcsi.science/0026-8984/article/view/138683
- DOI: https://doi.org/10.31857/S0026898423050130
- EDN: https://elibrary.ru/RLLOAN
- ID: 138683
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Resumo
Vasovagal syncope (VVS) is the most common form of syncope. The mechanisms of VVS development are not entirely clear. It is known that there is a genetic predisposition to this disease, but the data on the role of individual genes are quite contradictory. Recently, a genome-wide association study identified a locus at chromosome 2q32.1 associated with a united group of diseases – syncope and collapse; among the single nucleotide polymorphisms (SNPs) of this locus, the most significant association was observed for rs12465214. In a homogeneous sample of patients according to the diagnosis of VVS, we analyzed the association of rs12465214, rs12621296, rs17582219 and rs1344706 located on chromosome 2q32.1, with this form of syncope. In the enrolled set, only rs12621296 was associated with VVS by itself, whereas associations of other SNPs were observed only in biallelic combinations. An epistatic interaction between the components of the combination rs12621296*A + rs17582219*A was revealed. The possible involvement of individual genes localized in the 2q32.1 locus in the genetic architecture of the VVS is discussed.
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Sobre autores
N. Matveeva
National Medical Research Center for Cardiology named after academician E.I. Chazov,Ministry of Health of the Russian Federation; Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: natalijamat@rambler.ru
Russia, 121552, Moscow; Russia, 117997, Moscow
B. Titov
National Medical Research Center for Cardiology named after academician E.I. Chazov,Ministry of Health of the Russian Federation; Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: natalijamat@rambler.ru
Russia, 121552, Moscow; Russia, 117997, Moscow
E. Bazyleva
National Medical Research Center for Cardiology named after academician E.I. Chazov,Ministry of Health of the Russian Federation
Email: natalijamat@rambler.ru
Russia, 121552, Moscow
Е. Kuchinskaya
National Medical Research Center for Cardiology named after academician E.I. Chazov,Ministry of Health of the Russian Federation
Email: natalijamat@rambler.ru
Russia, 121552, Moscow
M. Kozin
National Medical Research Center for Cardiology named after academician E.I. Chazov,Ministry of Health of the Russian Federation; Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: natalijamat@rambler.ru
Russia, 121552, Moscow; Russia, 117997, Moscow
A. Favorov
Johns Hopkins School of Medicine
Email: natalijamat@rambler.ru
USA, 21205, Baltimore, MD
A. Pevzner
National Medical Research Center for Cardiology named after academician E.I. Chazov,Ministry of Health of the Russian Federation
Email: natalijamat@rambler.ru
Russia, 121552, Moscow
O. Favorova
National Medical Research Center for Cardiology named after academician E.I. Chazov,Ministry of Health of the Russian Federation; Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: natalijamat@rambler.ru
Russia, 121552, Moscow; Russia, 117997, Moscow
Bibliografia
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