Interleukin-11 in Pathology of the Nervous System

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Resumo

The study of the role of cytokines in various pathological conditions of the body is one of the topical areas of modern biomedicine. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been an increased interest in the cytokine in recent years. The cytokine plays a significant role in the central nervous system; local expression of this cytokine by nerve cells has been shown. Studies show the involvement of IL-11 in the mechanisms of development of a number of pathologies of the nervous system. The review summarizes information that shows the involvement of IL-11 in the mechanisms of development of brain pathologies. Probably, in the near future, this cytokine will be able to find clinical application in the correction of mechanisms that are involved in the formation of pathological conditions of the nervous system.

Sobre autores

M. Airapetov

Department of Pharmacology, St. Petersburg State Pediatric Medical University; Department of Neuropharmacology, Institute of Experimental Medicine

Email: erescko.sergei@yandex.ru
Russia, 194100, St. Petersburg; Russia, 197376, St. Petersburg

S. Eresko

Department of Neuropharmacology, Institute of Experimental Medicine; Research and Training Center of Molecular and Cellular Technologies,
St. Petersburg State Chemical Pharmaceutical University

Autor responsável pela correspondência
Email: erescko.sergei@yandex.ru
Russia, 197376, St. Petersburg; Russia, 197101, St. Petersburg

P. Ignatova

Department of Neuropharmacology, Institute of Experimental Medicine

Email: erescko.sergei@yandex.ru
Russia, 197376, St. Petersburg

A. Lebedev

Department of Neuropharmacology, Institute of Experimental Medicine

Email: erescko.sergei@yandex.ru
Russia, 197376, St. Petersburg

E. Bychkov

Department of Neuropharmacology, Institute of Experimental Medicine

Email: erescko.sergei@yandex.ru
Russia, 197376, St. Petersburg

P. Shabanov

Department of Neuropharmacology, Institute of Experimental Medicine; Department of Pharmacology, Kirov Military Medical Academy

Email: erescko.sergei@yandex.ru
Russia, 197376, St. Petersburg; Russia, 194044, St. Petersburg

Bibliografia

  1. Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O’Hara R.M., Jr., Leary A.C., Sibley B., Clark S.C., Williams D.A., Yang Y.C. (1990) Molecular cloning of a cDNA encoding interleukin 11, a stromal cell derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. USA. 87, 7512–7516.
  2. Heese K., Nagai Y., Sawada T. (2000) Induction of rat L-phosphoserine phosphatase by amyloid-beta (1-42) is inhibited by interleukin-11. Neurosci. Lett. 288(1), 37–40.
  3. Гук К.Д., Купраш Д.В. (2011) Интерлейкин-11, член семейства IL-6-подобных цитокинов. Молекуляр. биология. 45(1), 44–55.
  4. Wilde M.I., Faulds D. (1998) Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs. 10(2), 159–171.
  5. Einarsson O., Geba G.P., Zhu Z., Landry M., Elias J.A. (1996) Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. J. Clin. Investig. 97(4), 915–924.
  6. Tang W., Geba G.P., Zheng T., Ray P., Homer R.J., Kuhn C. (1996) Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J. Clin. Investig. 98(12), 2845–2853.
  7. Keller D.C., Du X.X., Srour E.F., Hoffman R., Williams D.A. (1993) Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures. Blood. 82(5), 1428–1435.
  8. Mehler M.F., Rozental R., Dougherty M., Spray D.C., Kessler J.A. (1993) Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature. 362(6415), 62–65.
  9. Leng S.X., Elias J.A. (1997) Interleukin-11. Int. J. Biochem. Cell. Biol. 29, 1059–1062.
  10. Gurfein B.T., Zhang Y., López C.B. (2009) IL-11 regulates autoimmune demyelination. J. Immunol. 183(7), 4229–4240.
  11. Maheshwari A., Janssens K., Bogie J., Van Den Haute C., Struys T., Lambrichts I., Baekelandt V., Stinissen P., Hendriks J.J., Slaets H., Hellings N. (2013) Local overexpression of interleukin-11 in the central nervous system limits demyelination and enhances remyelination. Mediators Inflamm. 2013, 685317.
  12. Zhang B., Zhang H.-X., Shi S.-T., Bai Y.-L., Zhe X., Zhang S.-J., Li Y.-J. (2019) Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury. Biomed. Pharmacother. 115, 108816.
  13. Горшкова Е.А., Недоспасов С.А., Шилов Е.С. (2016) Эволюционная пластичность цитокинов семейства IL-6. Молекуляр. биология. 50(6), 1039–1048.
  14. McKinley D., Wu Q., Yang-Feng T., Yang Y.C. (1992) Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). Genomics. 13(3), 814–819.
  15. Yang Y.C., Yin T. (1992) Interleukin-11 and its receptor. Biofactors. 4(1), 15–21.
  16. Stephen F.A., Thomas L.M., Alejandro A.S., Jinghui Z., Zheng Z., Webb M., David J.L. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucl. Acids Res. 25, 3389–3402.
  17. Barton V., Hall M., Hudson K.R., Heath J.K. (2000) Interleukin-11 signals through the formation of a hexameric receptor complex. J. Biol. Chem. 275(46), 36197–36203.
  18. Knut & Alice Wallenberg Foundation. IL-11. The Human Protein Atlas.
  19. Watanabe D., Yoshimura R., Khalil M., Yoshida K., Kishimoto T., Taga T., Kiyama H. (1996) Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain. Eur. J. Neurosci. 8(8), 1630–1640.
  20. Zhang Y., Chen K., Sloan S.A., Bennett M.L., Scholze A.R., O’Keeffe S., Phatnani H.P., Guarnieri P., Caneda C., Ruderisch N., Deng S., Liddelow S.A., Zhang C., Daneman R., Maniatis T., Barres B.A., Wu J.Q. (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34(36), 11929–11947.
  21. Zhang Y., Sloan S.A., Clarke L.E., Caneda C., Plaza C.A., Blumenthal P.D., Vogel H., Steinberg G.K., Edwards M.S., Li G., Duncan J.A., Cheshier S.H., Shuer L.M., Chang E.F., Grant G.A., Gephart M.G., Barres B.A. (2016) Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse. Neuron. 89(1), 37–53.
  22. Barton V., Hudson K.R., Heath J.K. (1999) Identification of three distinct receptor binding sites of murine interleukin-11. J. Biol. Chem. 274(9), 5755–5761.
  23. Tacken I., Dahmen H., Boisteau O., Minvielle S., Jacques Y., Grötzinger J. (1999) Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis. Eur. J. Biochem. 265(2), 645–655.
  24. Metcalfe R.D., Aizel K., Zlatic C.O., Nguyen P.M., Morton C.J., Lio. (2020) The structure of the extracellular domains of human interleukin 11 α-receptor reveals mechanisms of cytokine engagement. J. Biol. Chem. 295(24), 8285–8301.
  25. Lokau J., Agthe M., Flynn C.M., Garbers C. (2017) Proteolytic control of interleukin-11 and interleukin-6 biology. Biochim. Biophys. Acta Mol. Cell. Res. 1864(11 Pt B), 2105–2117.
  26. Montero A.J., Estrov Z., Freireich E.J., Khouri I.F., Koller C.A., Kurzrock R. (2006) Phase II study of low dose interleukin 11 in patients with myelodysplastic syndrome. Leuk. Lymphoma. 47, 2049–2054.
  27. Hatae M., Ariyoshi Y., Fukuoka M., Furuse K., Noda K., Hirabayashi K., Yakushiji M., Ogawa M., Takaku F. (2005) An early phase II clinical study of YM 294 (rhlL 11) in patients with solid tumors and malignant lymphoma. Gan To Kagaku Ryoho. 32, 489–496.
  28. Hatae M., Noda K., Yamamoto K., Ozaki M., Hiraba yashi K., Nishida T., Ohashi Y., Ogawa M., Takaku F. (2005) A clinical study of YM 294 (rhlL 11) in patients with gynecologic cancer. Gan To Kagaku Ryoho. 32, 479–487.
  29. Zhang Y., Taveggia C., Melendez-Vasquez C., Einheber S., Raine C.S., Salzer J.L., Brosnan C.F., John G.R. (2006) Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J. Neurosci. 26(47), 12174–12185.
  30. Zhang X., Tao Y., Chopra M., Dujmovic-Basuroski I., Jin J., Tang Y., Drulovic J., Markovic-Plese S. (2015) IL-11 induces Th17 cell responses in patients with early relapsing-remitting multiple sclerosis. J. Immunol. 194(11), 5139–5149.
  31. Trepicchio W.L., Wang L., Bozza M., Dorner A.J. (1997) IL-11 regulates macrophage effector function through the inhibition of nuclear factor-κB. J. Immunol. 159(11), 5661–5670.
  32. Leng S.X., Elias J.A. (1997) Interleukin-11 inhibits macrophage interleukin-12 production. J. Immunol. 159(5), 2161–2168.
  33. Sreenivasan L., Li L.V., Leclair P., Lim C.J. (2022) Targeting the gp130/STAT3 axis attenuates tumor microenvironment mediated chemoresistance in group 3 medulloblastoma cells. Cells. 11, 381.
  34. Airapetov M., Eresko S., Lebedev A., Bychkov E., Shabanov P. (2021) The role of Toll-like receptors in neurobiology of alcoholism. BioSci. Trends. 15(2), 74–82.
  35. Peterson P.K., Toborek M. (2014) Neuroinflammation Neurodegeneration. New York: Springer.

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Declaração de direitos autorais © М.И. Айрапетов, С.О. Ереско, П.Д. Игнатова, А.А. Лебедев, Е.Р. Бычков, П.Д. Шабанов, 2023

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