电邮这篇文章 Biomarkers of prostate cancer sensitivity to the Sendai virus
- 作者: Belova A.A.1, Sosnovtseva A.O.1,2, Lipatova A.V.1, Njushko K.M.3, Volchenko N.N.3, Belyakov M.M.3, Sudalenko O.V.3, Krasheninnikov A.A.3, Shegai P.V.3, Sadritdinova A.F.1,3, Fedorova M.S.1, Vorobjov N.V.3, Alekseev B.Y.3, Kaprin A.D.3, Kudryavtseva A.V.1,3
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隶属关系:
- Engelhardt Institute of Molecular Biology
- Pirogov Russian National Research Medical University
- National Medical Research Radiological Center
- 期: 卷 51, 编号 1 (2017)
- 页面: 80-88
- 栏目: Molecular Cell Biology
- URL: https://journals.rcsi.science/0026-8933/article/view/162962
- DOI: https://doi.org/10.1134/S0026893317010046
- ID: 162962
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详细
Metastatic prostate cancer is often associated with either primary or intractable castration-resistant prostate cancer (CRPC), thus justifying the search for entirely new ways of treatment. Oncolytic viruses are able to selectively induce the death of tumor cells without affecting normal cells. A murine Sendai virus has potential to be used as an oncolytic agent. However, tumors vary in their sensitivity to different viruses, prompting us to attempt to identify corresponding biomarkers that reflect the interaction of cancer cells and the virus. Here, we show that the sensitivity of primary prostatic adenocarcinoma cell lines to Sendai virus strain (SeVM) vary substantially. Using quantitative PCR, we evaluated expression levels of genes that encode RIG-1-like and Toll-like receptors (TLRs) in cell lines and showed that the levels of mRNAs that encode TLR3 and TLR7 correlate with a degree of sensitivity of the cells to Sendai virus. The lines with lower levels of TLR3 and TLR7 expression are more sensitive to the virus.
作者简介
A. Belova
Engelhardt Institute of Molecular Biology
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 119991
A. Sosnovtseva
Engelhardt Institute of Molecular Biology; Pirogov Russian National Research Medical University
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 119991; Moscow, 117997
A. Lipatova
Engelhardt Institute of Molecular Biology
编辑信件的主要联系方式.
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 119991
K. Njushko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
N. Volchenko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
M. Belyakov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
O. Sudalenko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
A. Krasheninnikov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
P. Shegai
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
A. Sadritdinova
Engelhardt Institute of Molecular Biology; National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 119991; Moscow, 125284
M. Fedorova
Engelhardt Institute of Molecular Biology
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 119991
N. Vorobjov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
B. Alekseev
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
A. Kaprin
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 125284
A. Kudryavtseva
Engelhardt Institute of Molecular Biology; National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
俄罗斯联邦, Moscow, 119991; Moscow, 125284
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