Отправить статью по E-mail Biomarkers of prostate cancer sensitivity to the Sendai virus
- Авторы: Belova A.A.1, Sosnovtseva A.O.1,2, Lipatova A.V.1, Njushko K.M.3, Volchenko N.N.3, Belyakov M.M.3, Sudalenko O.V.3, Krasheninnikov A.A.3, Shegai P.V.3, Sadritdinova A.F.1,3, Fedorova M.S.1, Vorobjov N.V.3, Alekseev B.Y.3, Kaprin A.D.3, Kudryavtseva A.V.1,3
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Учреждения:
- Engelhardt Institute of Molecular Biology
- Pirogov Russian National Research Medical University
- National Medical Research Radiological Center
- Выпуск: Том 51, № 1 (2017)
- Страницы: 80-88
- Раздел: Molecular Cell Biology
- URL: https://journals.rcsi.science/0026-8933/article/view/162962
- DOI: https://doi.org/10.1134/S0026893317010046
- ID: 162962
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Аннотация
Metastatic prostate cancer is often associated with either primary or intractable castration-resistant prostate cancer (CRPC), thus justifying the search for entirely new ways of treatment. Oncolytic viruses are able to selectively induce the death of tumor cells without affecting normal cells. A murine Sendai virus has potential to be used as an oncolytic agent. However, tumors vary in their sensitivity to different viruses, prompting us to attempt to identify corresponding biomarkers that reflect the interaction of cancer cells and the virus. Here, we show that the sensitivity of primary prostatic adenocarcinoma cell lines to Sendai virus strain (SeVM) vary substantially. Using quantitative PCR, we evaluated expression levels of genes that encode RIG-1-like and Toll-like receptors (TLRs) in cell lines and showed that the levels of mRNAs that encode TLR3 and TLR7 correlate with a degree of sensitivity of the cells to Sendai virus. The lines with lower levels of TLR3 and TLR7 expression are more sensitive to the virus.
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Об авторах
A. Belova
Engelhardt Institute of Molecular Biology
Email: lipatovaanv@gmail.com
Россия, Moscow, 119991
A. Sosnovtseva
Engelhardt Institute of Molecular Biology; Pirogov Russian National Research Medical University
Email: lipatovaanv@gmail.com
Россия, Moscow, 119991; Moscow, 117997
A. Lipatova
Engelhardt Institute of Molecular Biology
Автор, ответственный за переписку.
Email: lipatovaanv@gmail.com
Россия, Moscow, 119991
K. Njushko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
N. Volchenko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
M. Belyakov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
O. Sudalenko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
A. Krasheninnikov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
P. Shegai
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
A. Sadritdinova
Engelhardt Institute of Molecular Biology; National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 119991; Moscow, 125284
M. Fedorova
Engelhardt Institute of Molecular Biology
Email: lipatovaanv@gmail.com
Россия, Moscow, 119991
N. Vorobjov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
B. Alekseev
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
A. Kaprin
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 125284
A. Kudryavtseva
Engelhardt Institute of Molecular Biology; National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Россия, Moscow, 119991; Moscow, 125284
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