Role of the Nucleolus in Rearrangements of the IGH Locus


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Abstract

The review summarizes the results from a series of studies focusing on the role that the nucleolus plays in maturation of the IGH locus and the choice of its partner genes in leukemia-associated translocations. The role of nuclear compartmentalization and nuclear localization of translocated oncogenes in ectopic activation of their transcription is discussed.

About the authors

O. V. Iarovaia

Institute of Gene Biology; LIA1066 “Laboratoire franco-russe de recherche en oncologie”; CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy

Author for correspondence.
Email: iarovaia@inbox.ru
Russian Federation, Moscow, 119334; Villejuif; Villejuif, F-94805

E. S. Ioudinkova

Institute of Gene Biology; LIA1066 “Laboratoire franco-russe de recherche en oncologie”; CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy

Email: iarovaia@inbox.ru
Russian Federation, Moscow, 119334; Villejuif; Villejuif, F-94805

S. V. Razin

Institute of Gene Biology; LIA1066 “Laboratoire franco-russe de recherche en oncologie”; Biological Faculty

Email: iarovaia@inbox.ru
Russian Federation, Moscow, 119334; Villejuif; Moscow, 119991

Y. S. Vassetzky

LIA1066 “Laboratoire franco-russe de recherche en oncologie”; Biological Faculty; CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy

Email: iarovaia@inbox.ru
France, Villejuif; Moscow, 119991; Villejuif, F-94805

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