Role of the Nucleolus in Rearrangements of the IGH Locus


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The review summarizes the results from a series of studies focusing on the role that the nucleolus plays in maturation of the IGH locus and the choice of its partner genes in leukemia-associated translocations. The role of nuclear compartmentalization and nuclear localization of translocated oncogenes in ectopic activation of their transcription is discussed.

Sobre autores

O. Iarovaia

Institute of Gene Biology; LIA1066 “Laboratoire franco-russe de recherche en oncologie”; CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy

Autor responsável pela correspondência
Email: iarovaia@inbox.ru
Rússia, Moscow, 119334; Villejuif; Villejuif, F-94805

E. Ioudinkova

Institute of Gene Biology; LIA1066 “Laboratoire franco-russe de recherche en oncologie”; CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy

Email: iarovaia@inbox.ru
Rússia, Moscow, 119334; Villejuif; Villejuif, F-94805

S. Razin

Institute of Gene Biology; LIA1066 “Laboratoire franco-russe de recherche en oncologie”; Biological Faculty

Email: iarovaia@inbox.ru
Rússia, Moscow, 119334; Villejuif; Moscow, 119991

Y. Vassetzky

LIA1066 “Laboratoire franco-russe de recherche en oncologie”; Biological Faculty; CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy

Email: iarovaia@inbox.ru
França, Villejuif; Moscow, 119991; Villejuif, F-94805

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