Effect of Ascorbic Acid Isomeric Forms on Antibacterial Activity of Its Chitosan Salts

N. O. Gegel’; I. V. Zudina; O. N. Malinkina; A. B. Shipovskaya

doi:10.1134/S0026261718050107

Effect of Ascorbic Acid Isomeric Forms on Antibacterial Activity of Its Chitosan Salts

作者: Gegel’ N.O.¹, Zudina I.V.², Malinkina O.N.², Shipovskaya A.B.²
隶属关系:
1. Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences
2. Chernyshevsky Saratov State University
期: 卷 87, 编号 5 (2018)
页面: 732-737
栏目: Experimental Articles
URL: https://journals.rcsi.science/0026-2617/article/view/163717
DOI: https://doi.org/10.1134/S0026261718050107
ID: 163717

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Optical rotatory dispersion studies revealed water solutions of chitosan in L- and D-ascorbic acid to exhibit right rotation with anomalous dispersion and left rotation with normal dispersion, respectively. Microbiological investigation and transmission electron microscopy revealed the chitosan salt with D-ascorbic acid to cause deeper destructive changes than pure chitosan, which resulted in higher antibacterial activity against Staphylococcus aureus 209P and Escherichia coli 113-13.