CROSSLINKING AGENTS IN THE TARGETED DESIGN OF CHITOSAN-BASED MATERIALS

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

This review systematizes data on the mechanisms and features of using commercially available crosslinking agents — aldehydes (glutaraldehyde, genipin, aromatic monoaldehydes) and diglycidyl ethers — for the fabrication of chitosan- based materials. It is demonstrated that the choice of crosslinking agent, method, and conditions (pH, temperature, nature of the acid in the chitosan solution) enables a targeted control over the morphology, physicochemical properties, swelling and degradation kinetics, as well as the biocompatibility of the resulting hydrogels, films, and porous materials. The development of crosslinking strategies, including formations of dynamic covalent bonds and usage of macromolecular crosslinking agents, opens prospects for fabrication of injectable, self- healing, and stimulus- responsive systems for biomedical applications. Special attention is given to the cytotoxicity of traditional crosslinking agents through the use of less toxic alternatives (genipin, diglycidyl ethers) and methods that reduce the degree of crosslinking without significantly compromising the mechanical properties of the materials.

Негізгі сөздер

Авторлар туралы

N. Kildeeva

The Kosygin State University of Russia

Moscow, Russia

Yu. Privar

Institute of Chemistry, Far Eastern Branch, Russian Academy of Sciences

Vladivostok, Russia

S. Bratskaya

Institute of Chemistry, Far Eastern Branch, Russian Academy of Sciences; School of Medicine and Life Sciences, Far East Federal University

Email: sbratska@ich.dvo.ru
Vladivostok, Russia; Ajax Settlement, Russia

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