Radiation-Chemical Transformations of Ethylene Glycol and Its Deuterated Derivative
in Deaerated Aqueous Solutions

O. V. Urbanovich; Урбанович О. В.; A. I. Davydenko; Давыденко А. И.; R. L. Sverdlov; Свердлов Р. Л.; A. V. Bekish; Бекиш А. В.; S. B. Lastovskii; Ластовский С. Б.; E. V. Tochilin; Точилин Е. В.

doi:10.31857/S0023119323050133

Radiation-Chemical Transformations of Ethylene Glycol and Its Deuterated Derivative in Deaerated Aqueous Solutions

Authors: Urbanovich O.V.¹, Davydenko A.I.¹, Sverdlov R.L.¹^,2, Bekish A.V.³, Lastovskii S.B.⁴, Tochilin E.V.⁴
Affiliations:
1. Belarusian State University
2. Research Institute for Physicochemical Problems, Belarusian State Universit
3. Institute of Physical and Organic Chemistry, National Academy of Sciences of Belarus
4. Scientific and Practical Center for Materials Science, National Academy of Sciences of Belarus
Issue: Vol 57, No 5 (2023)
Pages: 363-368
Section: RADIATION CHEMISTRY
URL: https://journals.rcsi.science/0023-1193/article/view/139985
DOI: https://doi.org/10.31857/S0023119323050133
EDN: https://elibrary.ru/LWDXEF
ID: 139985

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Abstract

This study is devoted to the effect of complete deuteration of the ethylene glycol carbon skeleton on the formation of its radiation-induced free-radical transformations products in deaerated aqueous solutions at pH 7.00 ± 0.10 and a dose rate of 0.064 ± 0.002 Gy/s. It has been established that the chain process of fragmentation of carbon-centered ethylene glycol radicals (∙CH(OH)CH2OH) plays an important role in the formation of acetaldehyde. The replacement of protium atoms located at carbon atoms by deuterium decreased the radiation-chemical yield of acetaldehyde in aqueous 1 M solutions of diols by a factor of 8. The results of this study indicate that the use of deuterium exchange at the carbon skeleton of organic molecules is a promising way for increasing their resistance to radiation-induced free radical fragmentation processes.

Keywords

radiolysis, ethylene glycol, radical, free radical fragmentation, H–D isotope effect

References

Azzam E.I., Jay-Gerin J.-P., Pain D. // Cancer Lett. 2012. V. 327. P. 48.
Benderitter M., Vincent-Genod L., Pouget J.P. et al. // Radiat. Res. 2003. V. 159. P. 471.
Lehninger A.L., Nelson D.L., Cox M.M. Lehninger principles of biochemistry, 6th ed. Freeman W.H. New York, 2012.
Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine. Oxford: Oxford University Press, 2015.
Moskalenko I., Tikhonov I., Pliss E. et al. // Russian Journal of Physical Chemistry B. 2018. V. 12. № 6. P. 987.
Andreyev A.Y., Tsui H.S., Milne G.L. et al. // Free Radical Biology and Medicine. 2015. V. 82. P. 63.
Firsov A.M., Fomich M.A., Bekish A.V. et al. // The FEBS Journal. 2019. V. 286. № 11. P. 2099.
Carreau A., Hafny-Rahbi B.E., Matejuk A. et al. // J. Cell. Mol. Med. 2011. V. 15. P. 1239.
Петряев Е.П., Шадыро О.И. Радиационная химия бифункциональных органических соединений. Минск: Университетское, 1986.
Edimecheva I.P., Kisel R.M., Shadyro O.I. et al. // J. Radiat. Res. 2005. V. 46. P. 319.
Edimecheva I.P., Kisel M.A., Shadyro O.I. et al. // Int. J. Radiat. Biol. 1997. V. 71. P. 555.
Shadyro O., Lisovskaya A. // Chem. Phys. Lipids. 2019. V. 221. P. 176.
Shadyro O., Samovich S., Edimecheva I. // Free Radic. Biol. Med. 2019. V. 144. P. 6.
Shadyro O., Yurkova I., Kisel M. et al. // Free Radic. Biol. Med. 2004. V. 36. P. 1612.
Shadyro O.I., Yurkova I.L., Kisel M.A. // Int. J. Radiat. Biol. 2002. V. 78. P. 211.
Shadyro O.I., Yurkova I.L., Kisel M.A. et al. // Int. J. Radiat. Biol. 2004. V. 80. P. 239.
Sladkova A.A., Sosnovskaya A.A., Edimecheva I.P. et al. // Radiat. Phys. Chem. 2012. V. 81. P. 1896.
Ksendzova G.A., Sorokin V.L., Edimecheva I.P. et al. // Free Radical Research. 2004. V. 38. № 11. P. 1183.
Shadyro O.I., Glushonok G.K., Glushonok T.G. et al. // Free Radical Research. 2002. V. 36. P. 859.
Потоцкая Т.В., Шадыро О.И., Юркова И.Л. // Химия высоких энергий. 2004. Т. 38. С. 4.
Nepachalovich P.S., Shadyro O.I., Bekish A.V. et al. // Free Radical Research. 2020. V. 54. № 10. P. 732.
Термические константы веществ. Справочник / Под редакцией акад. В.П. Глушко, В.А. Медведева и др. Вып. 4. М.: ВИНИТИ, 1970.