Synthesis, Crystal Structure, and Anti-Gastric Cancer Activity of Ethyl 3-(3-Amino-4-(Methylamino)-N-(Pyridin-2-Yl) Benzamido)Propanoate

L.-Z. Liu; K.-Y. Peng; F.-R. Yue; X.-H. Li; L. Zhang

doi:10.1134/S0022476619120187

Synthesis, Crystal Structure, and Anti-Gastric Cancer Activity of Ethyl 3-(3-Amino-4-(Methylamino)-N-(Pyridin-2-Yl) Benzamido)Propanoate

Авторлар: Liu L.¹, Peng K.¹, Yue F.¹, Li X.¹, Zhang L.¹
Мекемелер:
1. Department of Oncology and Digestion
Шығарылым: Том 60, № 12 (2019)
Беттер: 2009-2014
Бөлім: Article
URL: https://journals.rcsi.science/0022-4766/article/view/162250
DOI: https://doi.org/10.1134/S0022476619120187
ID: 162250

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Аннотация

A new heterocyclic compound ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate (1), designed using 4-(methylamino)-3-nitrobenzoic acid (2) as a starting material is successfully obtained via a multiple synthesis route and finally characterized by IR, ¹H NMR, and single crystal X-ray crystallography. In addition, the in vitro anti-cancer activity of newly synthesized complex 1 is emulated against three human gastric cancer cell lines SGC-790, MKN-4, and MKN45.