Synthesis, Crystal Structure, and Anti-Gastric Cancer Activity of Ethyl 3-(3-Amino-4-(Methylamino)-N-(Pyridin-2-Yl) Benzamido)Propanoate
- Authors: Liu L.1, Peng K.1, Yue F.1, Li X.1, Zhang L.1
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Affiliations:
- Department of Oncology and Digestion
- Issue: Vol 60, No 12 (2019)
- Pages: 2009-2014
- Section: Article
- URL: https://journals.rcsi.science/0022-4766/article/view/162250
- DOI: https://doi.org/10.1134/S0022476619120187
- ID: 162250
Cite item
Abstract
A new heterocyclic compound ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate (1), designed using 4-(methylamino)-3-nitrobenzoic acid (2) as a starting material is successfully obtained via a multiple synthesis route and finally characterized by IR, 1H NMR, and single crystal X-ray crystallography. In addition, the in vitro anti-cancer activity of newly synthesized complex 1 is emulated against three human gastric cancer cell lines SGC-790, MKN-4, and MKN45.
Keywords
About the authors
L.-Z. Liu
Department of Oncology and Digestion
Email: li_zhang567@126.com
China, Chongqing
K.-Y. Peng
Department of Oncology and Digestion
Email: li_zhang567@126.com
China, Chongqing
F.-R. Yue
Department of Oncology and Digestion
Email: li_zhang567@126.com
China, Chongqing
X.-H. Li
Department of Oncology and Digestion
Email: li_zhang567@126.com
China, Chongqing
L. Zhang
Department of Oncology and Digestion
Author for correspondence.
Email: li_zhang567@126.com
China, Chongqing