The Role of Alpha-Tocopherol and Cycloferon in the Regulation of Apoptosis in Neurons of the Hypothalamic Suprachiasmatic Nucleus and Pinealocytes during Stress and Aging
- 作者: Khuzhakhmetova L.1, Belyaeva M.2, Teply D.3, Bazhanova E.3,2,4
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隶属关系:
- Astrakhan State Medical University
- Institute of Toxicology, Federal Medical and Biological Agency of Russia
- Astrakhan State University
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- 期: 卷 55, 编号 5 (2019)
- 页面: 380-387
- 栏目: Morphological Basics for Evolution of Functions
- URL: https://journals.rcsi.science/0022-0930/article/view/159808
- DOI: https://doi.org/10.1134/S0022093019050053
- ID: 159808
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详细
The suprachiasmatic nucleus (SCN) of the hypothalamus and the pineal gland (epiphysis) play an important role not only in the regulation of circadian rhythms but also in the implementation of adaptive responses, including those to various stress factors. Age-related morphofunctional changes in these brain structures, including those associated with increased oxidative stress, exert a significant effect on the organism as a whole. The aim of this work was to explore the dynamics and mechanism of apoptosis in pinealocytes and SCN neurosecretory cells as well as to determine the possibilities of pharmacological correcting this process by an antioxidant alpha-tocopherol and an immunomodulator cycloferon under physiological and immobilization stress conditions in young (2–4-month-old) and aged (30-month-old) Wistar rats. The preparations were administered perorally once a day for 14 days. While the apoptosis level increased with age both in the SCN and the pineal gland, administration of alpha-tocopherol, cycloferon and their combination led to abate this process. It was shown that stress-induced apoptosis in the SCN and the pineal gland proceeds via the p53-dependent pathway, while administration of alpha-tocopherol acetate, cycloferon and their combination decreases the apoptosis level in pinealocytes, suppressing p53 expression both in young and aged animals. In the SCN, no relationship was found between apoptosis and p53 expression levels after administration of the above preparations during stress, suggesting the involvement of different mechanisms.
作者简介
L. Khuzhakhmetova
Astrakhan State Medical University
Email: bazhanovae@mail.ru
俄罗斯联邦, Astrakhan
M. Belyaeva
Institute of Toxicology, Federal Medical and Biological Agency of Russia
Email: bazhanovae@mail.ru
俄罗斯联邦, St. Petersburg
D. Teply
Astrakhan State University
Email: bazhanovae@mail.ru
俄罗斯联邦, Astrakhan
E. Bazhanova
Astrakhan State University; Institute of Toxicology, Federal Medical and Biological Agency of Russia; Sechenov Institute of Evolutionary Physiology and Biochemistry
编辑信件的主要联系方式.
Email: bazhanovae@mail.ru
俄罗斯联邦, Astrakhan; St. Petersburg; St. Petersburg