T-cadherin as a novel receptor regulating metabolism in the blood vessel and heart cells: from structure to function
- Авторлар: Balatskaya M.1, Balatskii A.1, Sharonov G.1, Tkachuk V.1
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Мекемелер:
- Lomonosov Moscow State University
- Шығарылым: Том 52, № 2 (2016)
- Беттер: 103-118
- Бөлім: Reviews
- URL: https://journals.rcsi.science/0022-0930/article/view/159004
- DOI: https://doi.org/10.1134/S0022093016020010
- ID: 159004
Дәйексөз келтіру
Аннотация
The review discusses structural features of T-cadherin (T-cad) that allow it to perform functions other than cell–cell adhesion. T-cad is a receptor of the significant metabolic components, low-density lipoproteins and high-molecular-weight adiponectin. Association of cardiovascular and metabolic diseases with the T-cad gene polymorphism, as well as predominant T-cad expression in the cardiovascular system, cardioprotection and ischemic limb revascularization, depending on T-cad interaction with adiponectin, suggest a major role of this receptor in vascular and cardiac cell functioning. Possible mechanisms of T-cad-mediated regulation of metabolic processes are discussed.
Негізгі сөздер
Авторлар туралы
M. Balatskaya
Lomonosov Moscow State University
Хат алмасуға жауапты Автор.
Email: m.balatskaya@gmail.com
Ресей, Moscow
A. Balatskii
Lomonosov Moscow State University
Email: m.balatskaya@gmail.com
Ресей, Moscow
G. Sharonov
Lomonosov Moscow State University
Email: m.balatskaya@gmail.com
Ресей, Moscow
V. Tkachuk
Lomonosov Moscow State University
Email: m.balatskaya@gmail.com
Ресей, Moscow