Two-Level Organization of Thermogenesis in Adipose Tissue: a Morphofunctional Hypothesis
- Authors: Elsukova E.I.1
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Affiliations:
- V.P. Astafiev Krasnoyarsk State Pedagogical University
- Issue: Vol 55, No 5 (2019)
- Pages: 388-397
- Section: Problem Papers
- URL: https://journals.rcsi.science/0022-0930/article/view/159812
- DOI: https://doi.org/10.1134/S0022093019050065
- ID: 159812
Cite item
Abstract
A new hypothesis based on structural and molecular heterogeneity of thermogenic adipocytes suggests that regulated thermogenesis in mammalian adipose tissues involves two structural-functional levels. The first level comprises typical brown fat and beige adipocytes of subcutaneous white fat depots. Being a part of the functional thermoregulatory system, this level of heat production is controlled by the appropriate hypothalamic centers. The second level is represented by visceral beige adipocytes with a relatively low total thermogenic capacity which provide a fine local adjustment of thermal optima for cell renewal processes. This level is regulated mainly by the local auto- and paracrine mechanisms.
About the authors
E. I. Elsukova
V.P. Astafiev Krasnoyarsk State Pedagogical University
Author for correspondence.
Email: elsukova@kspu.ru
Russian Federation, Krasnoyarsk