Intensity of Lipid Peroxidation in the Crystalline Lens of the Rabbit Chinchilla brevicaudata Exposed to Hypoxia and Radiation in the Prenatal Period

Abstract

We address the redox homeostasis in the crystalline lens of the rabbit pups (aged 20 and 30 days) exposed to a combined effect of non-ionizing electromagnetic radiation (EMR) and hypoxia during their prenatal development. The intensity of lipid peroxidation (LPO) in the lens was in the focus of this study, being evaluated by a level of malondialdehyde (MDA), a final LPO product. It was established that prenatal exposure to 460-MHz non-ionizing EMR combined with hypoxia intensifies LPO. The obtained results allow some conclusions to be drawn about the mechanisms of antioxidant defense in relevant biological tissues. The necessity of further studies to prove the revealed tendencies is substantiated.