New Acylate and Thioacylate Effectors of Mammalian Cholinesterases Based on Cyclic Ammonium Alcohols Containing Elements of the Anabasine Structure
- Authors: Basova N.E.1, Kormilitsyn B.N.1, Perchenok A.Y.1, Rozengart E.V.1, Saakov V.S.1, Suvorov A.A.1
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Affiliations:
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- Issue: Vol 54, No 1 (2018)
- Pages: 22-29
- Section: Comparative and Ontogenic Biochemistry
- URL: https://journals.rcsi.science/0022-0930/article/view/159416
- DOI: https://doi.org/10.1134/S0022093018010039
- ID: 159416
Cite item
Abstract
We report a pioneering analysis of the interaction between mammalian cholinesterases and 36 acylates and thioacylates of ammonium alcohols with different structure of an alkyl chain between ammonium and etheric atoms and with different structure of a cyclic ammonium group. Among these ethers, which were both substrates and reversible inhibitors of erythrocyte cholinesterase and serum butyrylcholinesterase, specific effectors of both enzymes were identified.
About the authors
N. E. Basova
Sechenov Institute of Evolutionary Physiology and Biochemistry
Author for correspondence.
Email: basovn@rambler.ru
Russian Federation, St. Petersburg
B. N. Kormilitsyn
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: basovn@rambler.ru
Russian Federation, St. Petersburg
A. Yu. Perchenok
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: basovn@rambler.ru
Russian Federation, St. Petersburg
E. V. Rozengart
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: basovn@rambler.ru
Russian Federation, St. Petersburg
V. S. Saakov
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: basovn@rambler.ru
Russian Federation, St. Petersburg
A. A. Suvorov
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: basovn@rambler.ru
Russian Federation, St. Petersburg