Preparation of Bioactive Mesoporous Calcium Phosphate Granules

Abstract

Mesoporous calcium phosphate granules ranging in mesopore size from 11 to 19 nm have been prepared using cryogenic processing (–18°C) of gels and extrusion of calcium phosphate paste. The granules based on acid calcium phosphates have a relatively small specific surface area (45 m²/g) in comparison with the neutral and basic calcium phosphates (84–155 m²/g). Preclinical in vivo trials on rats show that the presence of calcium phosphate granules in a bone defect considerably accelerates reparative osteogenesis in comparison with a control group of animals.