Kinetics of Chemical Processes in the Human Brain. Trigger Effect and Self-Stabilization of N-Acetylaspartic Acid

Resumo

A kinetic model was proposed for the response of nerve tissue to an external signal stimulus. The model is based on the views of a multistep and non-linear nature of the dynamic variation of the concentrations of N-acetylaspartic acid and N-acetylaspartate in the human nerve tissue. The substrate inhibition effect in this system is a necessary factor for the self-stabilization of N-acetylaspartate as a key brain metabolite. The existence of three stationary states accounts for the trigger behavior of the system.