Kinetics of Chemical Processes in the Human Brain. Trigger Effect and Self-Stabilization of N-Acetylaspartic Acid
- Авторы: Varfolomeev S.D.1, Semenova N.A.2, Bykov V.I.2, Tsybenova S.B.2
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Учреждения:
- Department of Chemistry, Lomonosov Moscow State University
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Выпуск: Том 484, № 2 (2019)
- Страницы: 23-27
- Раздел: Physical Chemistry
- URL: https://journals.rcsi.science/0012-5016/article/view/153941
- DOI: https://doi.org/10.1134/S0012501619020039
- ID: 153941
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Аннотация
A kinetic model was proposed for the response of nerve tissue to an external signal stimulus. The model is based on the views of a multistep and non-linear nature of the dynamic variation of the concentrations of N-acetylaspartic acid and N-acetylaspartate in the human nerve tissue. The substrate inhibition effect in this system is a necessary factor for the self-stabilization of N-acetylaspartate as a key brain metabolite. The existence of three stationary states accounts for the trigger behavior of the system.
Об авторах
S. Varfolomeev
Department of Chemistry, Lomonosov MoscowState University
Email: vibykov@mail.ru
Россия, Moscow, 119991
N. Semenova
Emanuel Institute of Biochemical Physics,Russian Academy of Sciences
Email: vibykov@mail.ru
Россия, Moscow, 119991
V. Bykov
Emanuel Institute of Biochemical Physics,Russian Academy of Sciences
Автор, ответственный за переписку.
Email: vibykov@mail.ru
Россия, Moscow, 119991
S. Tsybenova
Emanuel Institute of Biochemical Physics,Russian Academy of Sciences
Email: vibykov@mail.ru
Россия, Moscow, 119991
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