Kinetics of Chemical Processes in the Human Brain: Modeling of the BOLD fMRI Signal

S. D. Varfolomeev; N. A. Semenova; V. I. Bykov; S. B. Tsybenova

doi:10.1134/S0012501619090057

Kinetics of Chemical Processes in the Human Brain: Modeling of the BOLD fMRI Signal

作者: Varfolomeev S.D.¹, Semenova N.A.², Bykov V.I.², Tsybenova S.B.²
隶属关系:
1. Institute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intelligence, Moscow State University
2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
期: 卷 488, 编号 1 (2019)
页面: 125-128
栏目: Physical Chemistry
URL: https://journals.rcsi.science/0012-5016/article/view/154039
DOI: https://doi.org/10.1134/S0012501619090057
ID: 154039

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详细

A kinetic model is presented that describes the pulse of the oxygen level increase in the excited nervous tissue of the human brain in response to an external signal. The model is based on biochemical data and describes experimental data on the hemodynamic impulse response. The model predicts the dynamic behavior of process participants preceding the oxygen pulse and determining the BOLD signal level.