电邮这篇文章 Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture
- 作者: Baikin A.S.1, Kaplan M.A.1, Nasakina E.O.1, Shatova L.A.2, Tsareva A.M.1, Kolmakova A.A.1, Danilova E.A.1, Tishurova Y.A.3,4, Bunkin N.F.3,4, Gudkov S.V.4,5,6, Belosludtsev K.N.7, Glinushkin A.P.6, Kolmakov A.G.1, Sevostyanov M.A.1,6,8
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隶属关系:
- Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
- Voronezh State Technical University
- Bauman Moscow State Technical University (National Research University)
- Prokhorov General Physics Institute, Russian Academy of Sciences
- Lobachevsky State University of Nizhny Novgorod— National Research University
- All-Russian Research Institute of Phytopathology
- Mari State University
- Ugresha Branch, State University “Dubna”
- 期: 卷 489, 编号 1 (2019)
- 页面: 261-263
- 栏目: Chemistry
- URL: https://journals.rcsi.science/0012-5008/article/view/154531
- DOI: https://doi.org/10.1134/S0012500819110041
- ID: 154531
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详细
A process was developed for producing biocompatible and biodegradable polymer films based on high-molecular-weight polylactide with properties necessary for medical and agricultural applications. A method was devised for the inclusion of active substances (gentamicin sulfate, lincomycin hydrochloride, or cefotaxime) into high-molecular-weight polylactide films. The rate of release of active substances from polylactide can vary with time according to a decaying exponential law or nearly linearly. The release of active substances is significantly affected by pH of the solution surrounding the film. It was found that the dynamics of release of active substances from biocompatible biodegradable polymer films based on high-molecular-weight polylactide depends on the properties of the immobilized substance, the film preparation method, and the conditions of extraction. The biocompatible biodegradable polymer films based on high-molecular-weight polylactide are quite suitable for the manufacture of coatings for stents and prostheses with prolonged and controlled drug release into the surrounding tissues and for agricultural applications to improve crop preservation.
作者简介
A. Baikin
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 119334
M. Kaplan
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 119334
E. Nasakina
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 119334
L. Shatova
Voronezh State Technical University
Email: baikinas@mail.ru
俄罗斯联邦, Voronezh, 394026
A. Tsareva
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 119334
A. Kolmakova
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 119334
E. Danilova
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 119334
Ya. Tishurova
Bauman Moscow State Technical University (National Research University); Prokhorov General Physics Institute, Russian Academyof Sciences
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 105043; Moscow
N. Bunkin
Bauman Moscow State Technical University (National Research University); Prokhorov General Physics Institute, Russian Academyof Sciences
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 105043; Moscow
S. Gudkov
Prokhorov General Physics Institute, Russian Academyof Sciences; Lobachevsky State University of Nizhny Novgorod— National Research University; All-Russian Research Institute of Phytopathology
Email: baikinas@mail.ru
俄罗斯联邦, Moscow; Nizhny Novgorod; Bolshie Vyazemy, Moscow oblast
K. Belosludtsev
Mari State University
Email: baikinas@mail.ru
俄罗斯联邦, Yoshkar-Ola
A. Glinushkin
All-Russian Research Institute of Phytopathology
Email: baikinas@mail.ru
俄罗斯联邦, Bolshie Vyazemy, Moscow oblast
A. Kolmakov
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 119334
M. Sevostyanov
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences; All-Russian Research Institute of Phytopathology; Ugresha Branch, State University “Dubna”
Email: baikinas@mail.ru
俄罗斯联邦, Moscow, 119334; Bolshie Vyazemy, Moscow oblast; Dzerzhynsk, Moscow oblast
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