Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture

A. S. Baikin; M. A. Kaplan; E. O. Nasakina; L. A. Shatova; A. M. Tsareva; A. A. Kolmakova; E. A. Danilova; Ya. A. Tishurova; N. F. Bunkin; S. V. Gudkov; K. N. Belosludtsev; A. P. Glinushkin; A. G. Kolmakov; M. A. Sevostyanov

doi:10.1134/S0012500819110041

Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture

Authors: Baikin A.S.¹, Kaplan M.A.¹, Nasakina E.O.¹, Shatova L.A.², Tsareva A.M.¹, Kolmakova A.A.¹, Danilova E.A.¹, Tishurova Y.A.³^,4, Bunkin N.F.³^,4, Gudkov S.V.⁴^,5^,6, Belosludtsev K.N.⁷, Glinushkin A.P.⁶, Kolmakov A.G.¹, Sevostyanov M.A.¹^,6^,8
Affiliations:
1. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
2. Voronezh State Technical University
3. Bauman Moscow State Technical University (National Research University)
4. Prokhorov General Physics Institute, Russian Academy of Sciences
5. Lobachevsky State University of Nizhny Novgorod— National Research University
6. All-Russian Research Institute of Phytopathology
7. Mari State University
8. Ugresha Branch, State University “Dubna”
Issue: Vol 489, No 1 (2019)
Pages: 261-263
Section: Chemistry
URL: https://journals.rcsi.science/0012-5008/article/view/154531
DOI: https://doi.org/10.1134/S0012500819110041
ID: 154531

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Abstract

A process was developed for producing biocompatible and biodegradable polymer films based on high-molecular-weight polylactide with properties necessary for medical and agricultural applications. A method was devised for the inclusion of active substances (gentamicin sulfate, lincomycin hydrochloride, or cefotaxime) into high-molecular-weight polylactide films. The rate of release of active substances from polylactide can vary with time according to a decaying exponential law or nearly linearly. The release of active substances is significantly affected by pH of the solution surrounding the film. It was found that the dynamics of release of active substances from biocompatible biodegradable polymer films based on high-molecular-weight polylactide depends on the properties of the immobilized substance, the film preparation method, and the conditions of extraction. The biocompatible biodegradable polymer films based on high-molecular-weight polylactide are quite suitable for the manufacture of coatings for stents and prostheses with prolonged and controlled drug release into the surrounding tissues and for agricultural applications to improve crop preservation.

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Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture

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About the authors

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