Email this article α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations
- Authors: Zamorina S.A.1,2, Timganova V.P.1, Bochkova M.S.1, Khramtsov P.V.1,2, Fomicheva K.A.2, Rayev M.B.1,2,3, Chereshnev V.A.1,2,3
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch
- Perm State National Research University
- Ural Federal University
- Issue: Vol 482, No 1 (2018)
- Pages: 210-213
- Section: Cell Biology
- URL: https://journals.rcsi.science/0012-4966/article/view/154389
- DOI: https://doi.org/10.1134/S0012496618050113
- ID: 154389
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Abstract
The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naïve T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.
About the authors
S. A. Zamorina
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm; Perm
V. P. Timganova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Author for correspondence.
Email: timganovavp@gmail.com
Russian Federation, Perm
M. S. Bochkova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: timganovavp@gmail.com
Russian Federation, Perm
P. V. Khramtsov
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm; Perm
K. A. Fomicheva
Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm
M. B. Rayev
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University; Ural Federal University
Email: timganovavp@gmail.com
Russian Federation, Perm; Perm; Yekaterinburg
V. A. Chereshnev
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University; Ural Federal University
Email: timganovavp@gmail.com
Russian Federation, Perm; Perm; Yekaterinburg
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