α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations

S. A. Zamorina; V. P. Timganova; M. S. Bochkova; P. V. Khramtsov; K. A. Fomicheva; M. B. Rayev; V. A. Chereshnev

doi:10.1134/S0012496618050113

α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations

作者: Zamorina S.A.¹^,2, Timganova V.P.¹, Bochkova M.S.¹, Khramtsov P.V.¹^,2, Fomicheva K.A.², Rayev M.B.¹^,2^,3, Chereshnev V.A.¹^,2^,3
隶属关系:
1. Institute of Ecology and Genetics of Microorganisms, Ural Branch
2. Perm State National Research University
3. Ural Federal University
期: 卷 482, 编号 1 (2018)
页面: 210-213
栏目: Cell Biology
URL: https://journals.rcsi.science/0012-4966/article/view/154389
DOI: https://doi.org/10.1134/S0012496618050113
ID: 154389

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The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naïve T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.

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α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations

全文:

详细

作者简介

S. Zamorina

V. Timganova

M. Bochkova

P. Khramtsov

K. Fomicheva

M. Rayev

V. Chereshnev

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