Changes in Microbiota and Development of Nonspecific Inflammation of Genitals in Female C57Bl/6 Mice after Aerosol Infection with Mycobacterium tuberculosis
- 作者: Kayukova S.1, Donnikov A.2, Bocharova I.1, Tumanova E.3, Gergert V.1, Ergeshov A.1, Nikonenko B.1
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隶属关系:
- Central Research Institute for Tuberculosis
- V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
- N. I. Pirogov Russian National Research Medical University
- 期: 卷 167, 编号 5 (2019)
- 页面: 645-649
- 栏目: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241983
- DOI: https://doi.org/10.1007/s10517-019-04589-8
- ID: 241983
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详细
Infectious process even at the initial stage after aerosol infection with Mycobacterium tuberculosis induced rapid changes in vaginal microbiota in mice. Rapid decrease in both the quantity and diversity of microbiota was noted, and then, partial recovery of normal flora was observed. Changes in vaginal microbiota was detected as soon as in 3-7 days after lung infection, while inflammatory changes appeared by day 35. At the early stage of infection, no signs of inflammation were observed, neither M. tuberculosis nor its DNA were detected in mouse genital organs.
作者简介
S. Kayukova
Central Research Institute for Tuberculosis
编辑信件的主要联系方式.
Email: kajukovavalnh@gmail.com
俄罗斯联邦, Moscow
A. Donnikov
V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: kajukovavalnh@gmail.com
俄罗斯联邦, Moscow
I. Bocharova
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
俄罗斯联邦, Moscow
E. Tumanova
N. I. Pirogov Russian National Research Medical University
Email: kajukovavalnh@gmail.com
俄罗斯联邦, Moscow
V. Gergert
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
俄罗斯联邦, Moscow
A. Ergeshov
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
俄罗斯联邦, Moscow
B. Nikonenko
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
俄罗斯联邦, Moscow