Changes in Microbiota and Development of Nonspecific Inflammation of Genitals in Female C57Bl/6 Mice after Aerosol Infection with Mycobacterium tuberculosis
- Authors: Kayukova S.I.1, Donnikov A.E.2, Bocharova I.V.1, Tumanova E.L.3, Gergert V.Y.1, Ergeshov A.E.1, Nikonenko B.V.1
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Affiliations:
- Central Research Institute for Tuberculosis
- V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
- N. I. Pirogov Russian National Research Medical University
- Issue: Vol 167, No 5 (2019)
- Pages: 645-649
- Section: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241983
- DOI: https://doi.org/10.1007/s10517-019-04589-8
- ID: 241983
Cite item
Abstract
Infectious process even at the initial stage after aerosol infection with Mycobacterium tuberculosis induced rapid changes in vaginal microbiota in mice. Rapid decrease in both the quantity and diversity of microbiota was noted, and then, partial recovery of normal flora was observed. Changes in vaginal microbiota was detected as soon as in 3-7 days after lung infection, while inflammatory changes appeared by day 35. At the early stage of infection, no signs of inflammation were observed, neither M. tuberculosis nor its DNA were detected in mouse genital organs.
About the authors
S. I. Kayukova
Central Research Institute for Tuberculosis
Author for correspondence.
Email: kajukovavalnh@gmail.com
Russian Federation, Moscow
A. E. Donnikov
V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: kajukovavalnh@gmail.com
Russian Federation, Moscow
I. V. Bocharova
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
Russian Federation, Moscow
E. L. Tumanova
N. I. Pirogov Russian National Research Medical University
Email: kajukovavalnh@gmail.com
Russian Federation, Moscow
V. Ya. Gergert
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
Russian Federation, Moscow
A. E. Ergeshov
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
Russian Federation, Moscow
B. V. Nikonenko
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
Russian Federation, Moscow