Changes in Microbiota and Development of Nonspecific Inflammation of Genitals in Female C57Bl/6 Mice after Aerosol Infection with Mycobacterium tuberculosis
- Авторлар: Kayukova S.1, Donnikov A.2, Bocharova I.1, Tumanova E.3, Gergert V.1, Ergeshov A.1, Nikonenko B.1
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Мекемелер:
- Central Research Institute for Tuberculosis
- V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
- N. I. Pirogov Russian National Research Medical University
- Шығарылым: Том 167, № 5 (2019)
- Беттер: 645-649
- Бөлім: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241983
- DOI: https://doi.org/10.1007/s10517-019-04589-8
- ID: 241983
Дәйексөз келтіру
Аннотация
Infectious process even at the initial stage after aerosol infection with Mycobacterium tuberculosis induced rapid changes in vaginal microbiota in mice. Rapid decrease in both the quantity and diversity of microbiota was noted, and then, partial recovery of normal flora was observed. Changes in vaginal microbiota was detected as soon as in 3-7 days after lung infection, while inflammatory changes appeared by day 35. At the early stage of infection, no signs of inflammation were observed, neither M. tuberculosis nor its DNA were detected in mouse genital organs.
Авторлар туралы
S. Kayukova
Central Research Institute for Tuberculosis
Хат алмасуға жауапты Автор.
Email: kajukovavalnh@gmail.com
Ресей, Moscow
A. Donnikov
V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: kajukovavalnh@gmail.com
Ресей, Moscow
I. Bocharova
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
Ресей, Moscow
E. Tumanova
N. I. Pirogov Russian National Research Medical University
Email: kajukovavalnh@gmail.com
Ресей, Moscow
V. Gergert
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
Ресей, Moscow
A. Ergeshov
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
Ресей, Moscow
B. Nikonenko
Central Research Institute for Tuberculosis
Email: kajukovavalnh@gmail.com
Ресей, Moscow
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