Effect of Cell-Penetrating Arginine Peptide on Interaction of Photosensitizer Chlorin e6 Incorporated into Phospholipid Nanoparticles with Tumor Cells
- 作者: Kostryukova L.1, Korotkevich E.1, Morozevich G.1, Kolesanova E.1, Mel’nikova M.1, Filatova Y.1, Torkhovskaya T.1, Prozorovskii V.1, Tikhonova E.1, Ipatova O.1
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隶属关系:
- V. N. Orekhovich Research Institute of Biomedical Chemistry
- 期: 卷 167, 编号 3 (2019)
- 页面: 347-350
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241692
- DOI: https://doi.org/10.1007/s10517-019-04524-x
- ID: 241692
如何引用文章
详细
We studied the possibility of increasing the efficiency of photodynamic therapy by improving delivery of photosensitizers chlorin e6 into tumor cells. Previous studies showed that incorporation of chlorin e6 onto phospholipid nanoparticles with a diameter <20 nm reduces its cytotoxicity due to accelerated elimination from organs [8]. A heptapeptide R7 synthesized and added to this combination promoted internalization of chlorin e6 into HepG2 cells in comparison with initial nanoparticles without peptide R7. The observed effect of peptide R7 can be explained by activation of endocytosis and/or macropinocytosis (bearing in mind the interaction of arginine with carboxyl groups of e6. The development of this transporting system is a promising trend in photodynamic therapy of cancer diseases.
作者简介
L. Kostryukova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
E. Korotkevich
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
G. Morozevich
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
E. Kolesanova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
M. Mel’nikova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
Yu. Filatova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
T. Torkhovskaya
V. N. Orekhovich Research Institute of Biomedical Chemistry
编辑信件的主要联系方式.
Email: torti@mail.ru
俄罗斯联邦, Moscow
V. Prozorovskii
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
E. Tikhonova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
O. Ipatova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
俄罗斯联邦, Moscow
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