Effect of Cell-Penetrating Arginine Peptide on Interaction of Photosensitizer Chlorin e6 Incorporated into Phospholipid Nanoparticles with Tumor Cells
- Авторы: Kostryukova L.1, Korotkevich E.1, Morozevich G.1, Kolesanova E.1, Mel’nikova M.1, Filatova Y.1, Torkhovskaya T.1, Prozorovskii V.1, Tikhonova E.1, Ipatova O.1
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Учреждения:
- V. N. Orekhovich Research Institute of Biomedical Chemistry
- Выпуск: Том 167, № 3 (2019)
- Страницы: 347-350
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241692
- DOI: https://doi.org/10.1007/s10517-019-04524-x
- ID: 241692
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Аннотация
We studied the possibility of increasing the efficiency of photodynamic therapy by improving delivery of photosensitizers chlorin e6 into tumor cells. Previous studies showed that incorporation of chlorin e6 onto phospholipid nanoparticles with a diameter <20 nm reduces its cytotoxicity due to accelerated elimination from organs [8]. A heptapeptide R7 synthesized and added to this combination promoted internalization of chlorin e6 into HepG2 cells in comparison with initial nanoparticles without peptide R7. The observed effect of peptide R7 can be explained by activation of endocytosis and/or macropinocytosis (bearing in mind the interaction of arginine with carboxyl groups of e6. The development of this transporting system is a promising trend in photodynamic therapy of cancer diseases.
Об авторах
L. Kostryukova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow
E. Korotkevich
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow
G. Morozevich
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow
E. Kolesanova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow
M. Mel’nikova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow
Yu. Filatova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow
T. Torkhovskaya
V. N. Orekhovich Research Institute of Biomedical Chemistry
Автор, ответственный за переписку.
Email: torti@mail.ru
Россия, Moscow
V. Prozorovskii
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow
E. Tikhonova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow
O. Ipatova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: torti@mail.ru
Россия, Moscow