Effects of Quercetin on Expression of Genes of Carbohydrate and Lipid Metabolism Enzymes in the Liver of Rats Receiving High-Fructose Ration
- 作者: Mzhel’skaya K.1, Trusov N.1, Guseva G.1, Aksenov I.1, Kravchenko L.1, Tutelyan V.1
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隶属关系:
- Federal Research Center of Nutrition and Biotechnology
- 期: 卷 167, 编号 2 (2019)
- 页面: 263-266
- 栏目: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/241634
- DOI: https://doi.org/10.1007/s10517-019-04505-0
- ID: 241634
如何引用文章
详细
We studied the expression of genes encoding enzymes of carbohydrate and lipid metabolism ketohexokinase (Khk), glucokinase (Gck), pyruvate kinase (Pklr), acetyl-Co-carboxylase (Acaca), fatty acid synthase (Fasn), stearoyl-CoA desaturase (Scd), and their transcription regulators ChREBP (Mlxipl), SREBP-1c (Srebf1), and PPARα (Ppara) in rat liver. Control group rats received a semisynthetic ration over 20 weeks. Experimental group 1 received a semisynthetic ration and 20% fructose solution instead of drinking water. Experimental group 2 rats received a semisynthetic ration with quercetin (0.1% fodder weight) and 20% fructose solution. Consumption of 20% fructose solution (experimental group 1) led to an increase in Scd expression in comparison with the control and did not affect the expression of other genes. Addition of quercetin to the ration (experimental group 2) led to a decrease in the expression of Khk, Gck, Fasn, Scd, Mlxipl, and Ppara genes in comparison with experimental group 1. The results suggest that quercetin reduced the expression of genes of carbohydrate and lipid metabolism enzymes in the liver of rats receiving high-fructose ration.
作者简介
K. Mzhel’skaya
Federal Research Center of Nutrition and Biotechnology
编辑信件的主要联系方式.
Email: kristik13@yandex.ru
俄罗斯联邦, Moscow
N. Trusov
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
俄罗斯联邦, Moscow
G. Guseva
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
俄罗斯联邦, Moscow
I. Aksenov
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
俄罗斯联邦, Moscow
L. Kravchenko
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
俄罗斯联邦, Moscow
V. Tutelyan
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
俄罗斯联邦, Moscow