State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

A. Yu. Mukhina; O. A. Medvedeva; M. V. Svishcheva; A. V. Shevchenko; N. N. Efremova; I. I. Bobyntsev; P. V. Kalutskii; L. A. Andreeva; N. F. Myasoedov

doi:10.1007/s10517-019-04496-y

State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

作者: Mukhina A.¹, Medvedeva O.¹, Svishcheva M.¹, Shevchenko A.¹, Efremova N.¹, Bobyntsev I.¹, Kalutskii P.¹, Andreeva L.², Myasoedov N.²
隶属关系:
1. Kursk State Medical University, Ministry of Health of the Russian Federation
2. Institute of Molecular Genetics, Russian Academy of Sciences
期: 卷 167, 编号 2 (2019)
页面: 226-228
栏目: Article
URL: https://journals.rcsi.science/0007-4888/article/view/241600
DOI: https://doi.org/10.1007/s10517-019-04496-y
ID: 241600

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We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.