State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment
- Authors: Mukhina A.Y.1, Medvedeva O.A.1, Svishcheva M.V.1, Shevchenko A.V.1, Efremova N.N.1, Bobyntsev I.I.1, Kalutskii P.V.1, Andreeva L.A.2, Myasoedov N.F.2
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Affiliations:
- Kursk State Medical University, Ministry of Health of the Russian Federation
- Institute of Molecular Genetics, Russian Academy of Sciences
- Issue: Vol 167, No 2 (2019)
- Pages: 226-228
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241600
- DOI: https://doi.org/10.1007/s10517-019-04496-y
- ID: 241600
Cite item
Abstract
We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.
About the authors
A. Yu. Mukhina
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Russian Federation, Kursk
O. A. Medvedeva
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Russian Federation, Kursk
M. V. Svishcheva
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Russian Federation, Kursk
A. V. Shevchenko
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Russian Federation, Kursk
N. N. Efremova
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Russian Federation, Kursk
I. I. Bobyntsev
Kursk State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: bobig@mail.ru
Russian Federation, Kursk
P. V. Kalutskii
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Russian Federation, Kursk
L. A. Andreeva
Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
Russian Federation, Moscow
N. F. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
Russian Federation, Moscow