Effect of Photoperiod and Lethal Yellow Mutation on Depression-Like Behavior and Expression of Proinflammatory Cytokines in the Hypothalamus in Mice
- 作者: Fursenko D.1, Bazhenova E.1, Khotskin N.1, Sorokin I.1, Kulikova E.1, Kulikov A.1
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隶属关系:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- 期: 卷 167, 编号 1 (2019)
- 页面: 100-103
- 栏目: Experimental Biology
- URL: https://journals.rcsi.science/0007-4888/article/view/241489
- DOI: https://doi.org/10.1007/s10517-019-04470-8
- ID: 241489
如何引用文章
详细
We studied the influence of obesity caused by lethal yellow (AY) mutation in the agouti gene, short photoperiod (4/20 h light/darkness), and combination of these factors on depressive-like behavior in the forced swimming test and expression of genes encoding proinflammatory cytokines in the hypothalamus of heterozygous male C57Bl/6-AY/a mice and their wild-type littermate controls (C57Bl/6-a/a). It was shown that AY mutation as well as short photoperiod increased depressive-like behavior in mice. No effect of the interaction of AY mutation and photoperiod on immobility in the forced swimming test was revealed. In wild-type mice, increased depressive-like behavior caused by short photoperiod was accompanied by enhanced expression of Tnf gene. Exposure to short daylight increased the expression of Nos2.
作者简介
D. Fursenko
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: dvfursenko@outlook.com
俄罗斯联邦, Novosibirsk
E. Bazhenova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
俄罗斯联邦, Novosibirsk
N. Khotskin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
俄罗斯联邦, Novosibirsk
I. Sorokin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
俄罗斯联邦, Novosibirsk
E. Kulikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
俄罗斯联邦, Novosibirsk
A. Kulikov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
俄罗斯联邦, Novosibirsk
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